Dexamethasone suppression test in positive and negative schizophrenia

Carlo Altamura, Grazia Guercetti, Mauro Percudani

Research output: Contribution to journalArticlepeer-review


Fifty-four inpatients with a DSM-III diagnosis of schizophrenia were studied. Patients were divided into positive and negative subtypes of schizophrenia according to Andreasen's criteria. Blood samples were obtained from all patients for 2 consecutive days to determine plasma cortisol concentrations before and after a single administration (1 mg, p.o.) of dexamethasone at 11 p.m. The results revealed a significant increase in plasma cortisol levels in schizophrenic patients, with 40% of the patients being nonsuppressors on the dexamethasone suppression test. A higher percentage (62.5%) of patients with the negative form of schizophrenia were nonsuppressors.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalPsychiatry Research
Issue number1
Publication statusPublished - 1989


  • cortisol
  • Dexamethasone suppression test
  • negative symptoms
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)


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