Dexamethasone suppression test in positive and negative schizophrenia

Carlo Altamura, Grazia Guercetti, Mauro Percudani

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Fifty-four inpatients with a DSM-III diagnosis of schizophrenia were studied. Patients were divided into positive and negative subtypes of schizophrenia according to Andreasen's criteria. Blood samples were obtained from all patients for 2 consecutive days to determine plasma cortisol concentrations before and after a single administration (1 mg, p.o.) of dexamethasone at 11 p.m. The results revealed a significant increase in plasma cortisol levels in schizophrenic patients, with 40% of the patients being nonsuppressors on the dexamethasone suppression test. A higher percentage (62.5%) of patients with the negative form of schizophrenia were nonsuppressors.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalPsychiatry Research
Volume30
Issue number1
DOIs
Publication statusPublished - 1989

Fingerprint

Dexamethasone
Schizophrenia
Hydrocortisone
Diagnostic and Statistical Manual of Mental Disorders
Inpatients

Keywords

  • cortisol
  • Dexamethasone suppression test
  • negative symptoms
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Dexamethasone suppression test in positive and negative schizophrenia. / Altamura, Carlo; Guercetti, Grazia; Percudani, Mauro.

In: Psychiatry Research, Vol. 30, No. 1, 1989, p. 69-75.

Research output: Contribution to journalArticle

Altamura, Carlo ; Guercetti, Grazia ; Percudani, Mauro. / Dexamethasone suppression test in positive and negative schizophrenia. In: Psychiatry Research. 1989 ; Vol. 30, No. 1. pp. 69-75.
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