Abstract
Fifty-four inpatients with a DSM-III diagnosis of schizophrenia were studied. Patients were divided into positive and negative subtypes of schizophrenia according to Andreasen's criteria. Blood samples were obtained from all patients for 2 consecutive days to determine plasma cortisol concentrations before and after a single administration (1 mg, p.o.) of dexamethasone at 11 p.m. The results revealed a significant increase in plasma cortisol levels in schizophrenic patients, with 40% of the patients being nonsuppressors on the dexamethasone suppression test. A higher percentage (62.5%) of patients with the negative form of schizophrenia were nonsuppressors.
| Original language | English |
|---|---|
| Pages (from-to) | 69-75 |
| Number of pages | 7 |
| Journal | Psychiatry Research |
| Volume | 30 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1989 |
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Keywords
- cortisol
- Dexamethasone suppression test
- negative symptoms
- schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Psychology(all)
Cite this
Dexamethasone suppression test in positive and negative schizophrenia. / Altamura, Carlo; Guercetti, Grazia; Percudani, Mauro.
In: Psychiatry Research, Vol. 30, No. 1, 1989, p. 69-75.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dexamethasone suppression test in positive and negative schizophrenia
AU - Altamura, Carlo
AU - Guercetti, Grazia
AU - Percudani, Mauro
PY - 1989
Y1 - 1989
N2 - Fifty-four inpatients with a DSM-III diagnosis of schizophrenia were studied. Patients were divided into positive and negative subtypes of schizophrenia according to Andreasen's criteria. Blood samples were obtained from all patients for 2 consecutive days to determine plasma cortisol concentrations before and after a single administration (1 mg, p.o.) of dexamethasone at 11 p.m. The results revealed a significant increase in plasma cortisol levels in schizophrenic patients, with 40% of the patients being nonsuppressors on the dexamethasone suppression test. A higher percentage (62.5%) of patients with the negative form of schizophrenia were nonsuppressors.
AB - Fifty-four inpatients with a DSM-III diagnosis of schizophrenia were studied. Patients were divided into positive and negative subtypes of schizophrenia according to Andreasen's criteria. Blood samples were obtained from all patients for 2 consecutive days to determine plasma cortisol concentrations before and after a single administration (1 mg, p.o.) of dexamethasone at 11 p.m. The results revealed a significant increase in plasma cortisol levels in schizophrenic patients, with 40% of the patients being nonsuppressors on the dexamethasone suppression test. A higher percentage (62.5%) of patients with the negative form of schizophrenia were nonsuppressors.
KW - cortisol
KW - Dexamethasone suppression test
KW - negative symptoms
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=0024458440&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024458440&partnerID=8YFLogxK
U2 - 10.1016/0165-1781(89)90173-X
DO - 10.1016/0165-1781(89)90173-X
M3 - Article
C2 - 2594873
AN - SCOPUS:0024458440
VL - 30
SP - 69
EP - 75
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 1
ER -