Dexamethasone suppression test, melatonin and TRH-test in cluster headache

M. Leone, F. Frediani, D. D'Amico, G. Patruno, S. Valentini, E. A. Parati, G. Bussone

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The origin of Cluster Headache (CH) is still unknown. The periodicty and presence of symptoms due to both sympathetic and parasympathetic activity suggest the involvement of central nervous system structures, particularly the hypothalamus. To investigate hypothalamic involvement in CH, we employed a neuroendocrinological approach. We observed a normal dexamethasone suppression test (DST) in all patients, increased cortisol plasma levels in remission patients at 8.00am before and at the end of the DST, while only in CH patients during cluster period did we find a reduced TSH response to TRH and a reduced night-time melatonin peak. The neuroendocrinological derangements found in CH may be consistent with hypothalamic involvement.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalItalian Journal of Neurological Sciences
Issue number3
Publication statusPublished - Apr 1992


  • Cluster headache
  • hypothalamic involvement
  • night-time melatonin peak
  • plasma cortisol levels
  • THS response to TRH

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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