Dexamethasone therapy in preterm infants developing bronchopulmonary dysplasia: Effect on pulmonary surfactant disaturated-phosphatidylcholine kinetics

Paola E. Cogo, Manuela Simonato, Gianna Mariatoffolo, Giorgio Stefanutti, Marco Chierici, Claudio Cobelli, Carlo Ori, Virgilio P. Carnielli

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The role of corticosteroid in severe bronchopulmonary dyplasia (BPD) is still debated. Scanty data are available on the corticosteroids effect on surfactant metabolism. Our objective was to compare surfactant kinetics in preterm infants with developing BPD, before and after dexamethasone (DEXA) treatment. Twenty-eight studies were performed in 14 preterm infants (birth weight 786 ± 192 g, gestational age 26 ± 1 wk) on high ventilatory setting, before (age 22 ± 11 d) and after (age 33 ± 11 d) DEXA. C-labeled dipalmitoyl-phosphatidylcholine (DPPC) was administered endotrachelly to trace pulmonary surfactant. Surfactant disaturated-phosphatidylcholine (DSPC) kinetics and pools were calculated from DSPC C-enrichment curves of serial tracheal aspirates and bi-compartmental analysis. Total protein and myeloperoxidase (MPO) activity in tracheal aspirates were also measured and expressed per ml of Epithelial Lining Fluid (ELF). After DEXA, DSPC alveolar pool increased significantly from 8.2 ± 7.6 to 10.6 ± 11.3 mg/kg (p = 0.039), total proteins and MPO were reduced from 8.8 ± 8.6 to 3.1 ± 2.1 mg/ml ELF (p = 0.046) and from 1822 ± 1224 to 1261 ± 987 mU/mlELF (p = 0.028) respectively. In conclusion, DEXA treatment in mechanically ventilated preterm infants with severe respiratory failure and at high risk of developing BPD, significantly reduced inflammatory markers and increased alveolar surfactant DSPC pool.

Original languageEnglish
Pages (from-to)433-437
Number of pages5
JournalPediatric Research
Volume63
Issue number4
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Pulmonary Surfactants
Bronchopulmonary Dysplasia
Premature Infants
Surface-Active Agents
Dexamethasone
Peroxidase
Adrenal Cortex Hormones
1,2-Dipalmitoylphosphatidylcholine
Premature Birth
Therapeutics
Birth Weight
Respiratory Insufficiency
Gestational Age
Proteins
disaturated lecithin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Dexamethasone therapy in preterm infants developing bronchopulmonary dysplasia : Effect on pulmonary surfactant disaturated-phosphatidylcholine kinetics. / Cogo, Paola E.; Simonato, Manuela; Mariatoffolo, Gianna; Stefanutti, Giorgio; Chierici, Marco; Cobelli, Claudio; Ori, Carlo; Carnielli, Virgilio P.

In: Pediatric Research, Vol. 63, No. 4, 04.2008, p. 433-437.

Research output: Contribution to journalArticle

Cogo, PE, Simonato, M, Mariatoffolo, G, Stefanutti, G, Chierici, M, Cobelli, C, Ori, C & Carnielli, VP 2008, 'Dexamethasone therapy in preterm infants developing bronchopulmonary dysplasia: Effect on pulmonary surfactant disaturated-phosphatidylcholine kinetics', Pediatric Research, vol. 63, no. 4, pp. 433-437. https://doi.org/10.1203/PDR.0b013e3181659759
Cogo, Paola E. ; Simonato, Manuela ; Mariatoffolo, Gianna ; Stefanutti, Giorgio ; Chierici, Marco ; Cobelli, Claudio ; Ori, Carlo ; Carnielli, Virgilio P. / Dexamethasone therapy in preterm infants developing bronchopulmonary dysplasia : Effect on pulmonary surfactant disaturated-phosphatidylcholine kinetics. In: Pediatric Research. 2008 ; Vol. 63, No. 4. pp. 433-437.
@article{fbce8f276edf42258d0f5dfc8b77fdcc,
title = "Dexamethasone therapy in preterm infants developing bronchopulmonary dysplasia: Effect on pulmonary surfactant disaturated-phosphatidylcholine kinetics",
abstract = "The role of corticosteroid in severe bronchopulmonary dyplasia (BPD) is still debated. Scanty data are available on the corticosteroids effect on surfactant metabolism. Our objective was to compare surfactant kinetics in preterm infants with developing BPD, before and after dexamethasone (DEXA) treatment. Twenty-eight studies were performed in 14 preterm infants (birth weight 786 ± 192 g, gestational age 26 ± 1 wk) on high ventilatory setting, before (age 22 ± 11 d) and after (age 33 ± 11 d) DEXA. C-labeled dipalmitoyl-phosphatidylcholine (DPPC) was administered endotrachelly to trace pulmonary surfactant. Surfactant disaturated-phosphatidylcholine (DSPC) kinetics and pools were calculated from DSPC C-enrichment curves of serial tracheal aspirates and bi-compartmental analysis. Total protein and myeloperoxidase (MPO) activity in tracheal aspirates were also measured and expressed per ml of Epithelial Lining Fluid (ELF). After DEXA, DSPC alveolar pool increased significantly from 8.2 ± 7.6 to 10.6 ± 11.3 mg/kg (p = 0.039), total proteins and MPO were reduced from 8.8 ± 8.6 to 3.1 ± 2.1 mg/ml ELF (p = 0.046) and from 1822 ± 1224 to 1261 ± 987 mU/mlELF (p = 0.028) respectively. In conclusion, DEXA treatment in mechanically ventilated preterm infants with severe respiratory failure and at high risk of developing BPD, significantly reduced inflammatory markers and increased alveolar surfactant DSPC pool.",
author = "Cogo, {Paola E.} and Manuela Simonato and Gianna Mariatoffolo and Giorgio Stefanutti and Marco Chierici and Claudio Cobelli and Carlo Ori and Carnielli, {Virgilio P.}",
year = "2008",
month = "4",
doi = "10.1203/PDR.0b013e3181659759",
language = "English",
volume = "63",
pages = "433--437",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Dexamethasone therapy in preterm infants developing bronchopulmonary dysplasia

T2 - Effect on pulmonary surfactant disaturated-phosphatidylcholine kinetics

AU - Cogo, Paola E.

AU - Simonato, Manuela

AU - Mariatoffolo, Gianna

AU - Stefanutti, Giorgio

AU - Chierici, Marco

AU - Cobelli, Claudio

AU - Ori, Carlo

AU - Carnielli, Virgilio P.

PY - 2008/4

Y1 - 2008/4

N2 - The role of corticosteroid in severe bronchopulmonary dyplasia (BPD) is still debated. Scanty data are available on the corticosteroids effect on surfactant metabolism. Our objective was to compare surfactant kinetics in preterm infants with developing BPD, before and after dexamethasone (DEXA) treatment. Twenty-eight studies were performed in 14 preterm infants (birth weight 786 ± 192 g, gestational age 26 ± 1 wk) on high ventilatory setting, before (age 22 ± 11 d) and after (age 33 ± 11 d) DEXA. C-labeled dipalmitoyl-phosphatidylcholine (DPPC) was administered endotrachelly to trace pulmonary surfactant. Surfactant disaturated-phosphatidylcholine (DSPC) kinetics and pools were calculated from DSPC C-enrichment curves of serial tracheal aspirates and bi-compartmental analysis. Total protein and myeloperoxidase (MPO) activity in tracheal aspirates were also measured and expressed per ml of Epithelial Lining Fluid (ELF). After DEXA, DSPC alveolar pool increased significantly from 8.2 ± 7.6 to 10.6 ± 11.3 mg/kg (p = 0.039), total proteins and MPO were reduced from 8.8 ± 8.6 to 3.1 ± 2.1 mg/ml ELF (p = 0.046) and from 1822 ± 1224 to 1261 ± 987 mU/mlELF (p = 0.028) respectively. In conclusion, DEXA treatment in mechanically ventilated preterm infants with severe respiratory failure and at high risk of developing BPD, significantly reduced inflammatory markers and increased alveolar surfactant DSPC pool.

AB - The role of corticosteroid in severe bronchopulmonary dyplasia (BPD) is still debated. Scanty data are available on the corticosteroids effect on surfactant metabolism. Our objective was to compare surfactant kinetics in preterm infants with developing BPD, before and after dexamethasone (DEXA) treatment. Twenty-eight studies were performed in 14 preterm infants (birth weight 786 ± 192 g, gestational age 26 ± 1 wk) on high ventilatory setting, before (age 22 ± 11 d) and after (age 33 ± 11 d) DEXA. C-labeled dipalmitoyl-phosphatidylcholine (DPPC) was administered endotrachelly to trace pulmonary surfactant. Surfactant disaturated-phosphatidylcholine (DSPC) kinetics and pools were calculated from DSPC C-enrichment curves of serial tracheal aspirates and bi-compartmental analysis. Total protein and myeloperoxidase (MPO) activity in tracheal aspirates were also measured and expressed per ml of Epithelial Lining Fluid (ELF). After DEXA, DSPC alveolar pool increased significantly from 8.2 ± 7.6 to 10.6 ± 11.3 mg/kg (p = 0.039), total proteins and MPO were reduced from 8.8 ± 8.6 to 3.1 ± 2.1 mg/ml ELF (p = 0.046) and from 1822 ± 1224 to 1261 ± 987 mU/mlELF (p = 0.028) respectively. In conclusion, DEXA treatment in mechanically ventilated preterm infants with severe respiratory failure and at high risk of developing BPD, significantly reduced inflammatory markers and increased alveolar surfactant DSPC pool.

UR - http://www.scopus.com/inward/record.url?scp=41349100963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41349100963&partnerID=8YFLogxK

U2 - 10.1203/PDR.0b013e3181659759

DO - 10.1203/PDR.0b013e3181659759

M3 - Article

C2 - 18356753

AN - SCOPUS:41349100963

VL - 63

SP - 433

EP - 437

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 4

ER -