Dextrorphan and dextromethorphan: Comparative antitussive effects on guinea pigs

P. C. Braga, A. Fossati, M. G. Vimercati, R. Caputo, E. E. Guffanti

Research output: Contribution to journalArticlepeer-review

Abstract

Dextromethorphan, after administration, is rapidly and extensively transformed into dextrorphan. The aim of this study was to compare the cough-suppressing activity of 6, 12, 24, 48 mg/kg, i.p., of dextrorphan (dextro rotatory isomer of racemorphan) with that of dextromethorphan, using the model of citric acid-induced coughing in the unanaesthetized, unrestrained guinea pig. A significant dose-effect relationship of dextrorphan in reducing citric acid-induced cough was observed. This effect was comparable with that of dextromethorphan. However, at 48 mg/kg, i.p., dextromethorphan had a toxic effect while dextrorphan did not. Because dextrorphan is the major metabolite of dextromethorphan and has antitussive activity comparable to that of dextromethorphan, clinical use of dextrorphan is suggested.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalDrugs under Experimental and Clinical Research
Volume20
Issue number5
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology

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