Diabetes and obesity as independent risk factors for osteoporosis: Updated results from the ROIS/EMEROS registry in a population of five thousand post-menopausalwomen living in a region characterized by heavy environmental pressure

Cosimo Neglia, Alberto Argentiero, Giovanna Chitano, Nadia Agnello, Roberta Ciccarese, Antonella Vigilanza, Valerio Pantile, Domenico Argentiero, Raffaele Quarta, Matteo Rivezzi, Gian Luca Di Tanna, Carolina Di Somma, Alberto Migliore, Giovanni Iolascon, Francesca Gimigliano, Alessandro Distante, Prisco Piscitelli

Research output: Contribution to journalArticle

Abstract

Objectives: We aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women. Methods: We found 4909 postmenopausal subjects within ≥10,000 records from the ROIS/EMEROS (Ionian and Salento Osteoporosis Registry/Euro Mediterranean Registry of Osteoporosis) registry, a population study carried out in an area characterized by heavy environmental pressure between Brindisi and Taranto from 2009 to 2016. All subjects were assessed via phalangeal quantitative ultrasound (QUS) to evaluate their bone mineralization (assessed via amplitude dependent speed of sound (AD-SoS)) and the association between demineralization and the presence of other conditions or risk factors. Results: Mean age was 64 ± 9.5 years and mean body mass index (BMI) was 28.7 ± 3.5 kg/m2. Pearson correlation analyses revealed a negative association between bone mineralization (AD-SoS) and BMI (p < 0.001). By using multivariate logistic regression analysis, we observed significant values of odds ratios (ORs) of osteoporosis (adjusted for age, physical activity, and the use of drugs known to increase the risk of fractures) in subjects with diabetes and obesity: 1.39 (confidence interval (CI): 1.05-1.83) and 1.46 (CI: 1.20-1.78), respectively. A statistically significant linear trend of higher ORs of osteoporosis was found for increasing values of BMI. Conclusions: Our study confirmed the high impact of obesity and type 1 and type 2 diabetes on osteoporosis.

Original languageEnglish
Article number1067
JournalInternational Journal of Environmental Research and Public Health
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

Keywords

  • Diabetes
  • Environmental factors
  • Fractures
  • Obesity
  • Osteoporosis
  • Quantitative ultrasounds

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Diabetes and obesity as independent risk factors for osteoporosis: Updated results from the ROIS/EMEROS registry in a population of five thousand post-menopausalwomen living in a region characterized by heavy environmental pressure'. Together they form a unique fingerprint.

  • Cite this

    Neglia, C., Argentiero, A., Chitano, G., Agnello, N., Ciccarese, R., Vigilanza, A., Pantile, V., Argentiero, D., Quarta, R., Rivezzi, M., Luca Di Tanna, G., Di Somma, C., Migliore, A., Iolascon, G., Gimigliano, F., Distante, A., & Piscitelli, P. (2016). Diabetes and obesity as independent risk factors for osteoporosis: Updated results from the ROIS/EMEROS registry in a population of five thousand post-menopausalwomen living in a region characterized by heavy environmental pressure. International Journal of Environmental Research and Public Health, 13(11), [1067]. https://doi.org/10.3390/ijerph13111067