Diabetes and onset of natural menopause: Results from the European Prospective Investigation into Cancer and Nutrition

J. S. Brand, N. C. Onland-Moret, M. J C Eijkemans, A. Tjønneland, N. Roswall, K. Overvad, G. Fagherazzi, F. Clavel-Chapelon, L. Dossus, A. Lukanova, V. Grote, M. M. Bergmann, H. Boeing, A. Trichopoulou, M. Tzivoglou, D. Trichopoulos, S. Grioni, A. Mattiello, G. Masala, R. TuminoP. Vineis, H. B. Bueno-De-Mesquita, E. Weiderpass, M. L. Redondo, M. J. Sánchez, J. M Huerta Castaño, L. Arriola, E. Ardanaz, E. J. Duell, O. Rolandsson, P. W. Franks, S. Butt, P. Nilsson, K. T. Khaw, N. Wareham, R. Travis, I. Romieu, M. J. Gunter, E. Riboli, Y. T. Van Der Schouw

Research output: Contribution to journalArticlepeer-review


STUDY QUESTION Do women who have diabetes before menopause have their menopause at an earlier age compared with women without diabetes? SUMMARY ANSWER Although there was no overall association between diabetes and age at menopause, our study suggests that early-onset diabetes may accelerate menopause. WHAT IS KNOWN ALREADY Today, more women of childbearing age are being diagnosed with diabetes, but little is known about the impact of diabetes on reproductive health. STUDY DESIGN, SIZE, DURATION We investigated the impact of diabetes on age at natural menopause (ANM) in 258 898 women from the European Prospective Investigation into Cancer and Nutrition (EPIC), enrolled between 1992 and 2000. PARTICIPANTS/MATERIALS, SETTING, METHODS Determinant and outcome information was obtained through questionnaires. Time-dependent Cox regression analyses were used to estimate the associations of diabetes and age at diabetes diagnosis with ANM, stratified by center and adjusted for age, smoking, reproductive and diabetes risk factors and with age from birth to menopause or censoring as the underlying time scale. MAIN RESULTS AND THE ROLE OF CHANCE Overall, no association between diabetes and ANM was found (hazard ratio (HR) = 0.94; 95% confidence interval (CI) 0.89-1.01). However, women with diabetes before the age of 20 years had an earlier menopause (10-20 years: HR = 1.43; 95% CI 1.02-2.01,

Original languageEnglish
Pages (from-to)1491-1498
Number of pages8
JournalHuman Reproduction
Issue number6
Publication statusPublished - Mar 18 2015


  • age at natural menopause
  • cox proportional hazards analyses
  • diabetes
  • time-dependent modeling

ASJC Scopus subject areas

  • Rehabilitation
  • Obstetrics and Gynaecology
  • Reproductive Medicine


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