TY - JOUR
T1 - Diabetes and onset of natural menopause
T2 - Results from the European Prospective Investigation into Cancer and Nutrition
AU - Brand, J. S.
AU - Onland-Moret, N. C.
AU - Eijkemans, M. J C
AU - Tjønneland, A.
AU - Roswall, N.
AU - Overvad, K.
AU - Fagherazzi, G.
AU - Clavel-Chapelon, F.
AU - Dossus, L.
AU - Lukanova, A.
AU - Grote, V.
AU - Bergmann, M. M.
AU - Boeing, H.
AU - Trichopoulou, A.
AU - Tzivoglou, M.
AU - Trichopoulos, D.
AU - Grioni, S.
AU - Mattiello, A.
AU - Masala, G.
AU - Tumino, R.
AU - Vineis, P.
AU - Bueno-De-Mesquita, H. B.
AU - Weiderpass, E.
AU - Redondo, M. L.
AU - Sánchez, M. J.
AU - Castaño, J. M Huerta
AU - Arriola, L.
AU - Ardanaz, E.
AU - Duell, E. J.
AU - Rolandsson, O.
AU - Franks, P. W.
AU - Butt, S.
AU - Nilsson, P.
AU - Khaw, K. T.
AU - Wareham, N.
AU - Travis, R.
AU - Romieu, I.
AU - Gunter, M. J.
AU - Riboli, E.
AU - Van Der Schouw, Y. T.
PY - 2015/3/18
Y1 - 2015/3/18
N2 - STUDY QUESTION Do women who have diabetes before menopause have their menopause at an earlier age compared with women without diabetes? SUMMARY ANSWER Although there was no overall association between diabetes and age at menopause, our study suggests that early-onset diabetes may accelerate menopause. WHAT IS KNOWN ALREADY Today, more women of childbearing age are being diagnosed with diabetes, but little is known about the impact of diabetes on reproductive health. STUDY DESIGN, SIZE, DURATION We investigated the impact of diabetes on age at natural menopause (ANM) in 258 898 women from the European Prospective Investigation into Cancer and Nutrition (EPIC), enrolled between 1992 and 2000. PARTICIPANTS/MATERIALS, SETTING, METHODS Determinant and outcome information was obtained through questionnaires. Time-dependent Cox regression analyses were used to estimate the associations of diabetes and age at diabetes diagnosis with ANM, stratified by center and adjusted for age, smoking, reproductive and diabetes risk factors and with age from birth to menopause or censoring as the underlying time scale. MAIN RESULTS AND THE ROLE OF CHANCE Overall, no association between diabetes and ANM was found (hazard ratio (HR) = 0.94; 95% confidence interval (CI) 0.89-1.01). However, women with diabetes before the age of 20 years had an earlier menopause (10-20 years: HR = 1.43; 95% CI 1.02-2.01,
AB - STUDY QUESTION Do women who have diabetes before menopause have their menopause at an earlier age compared with women without diabetes? SUMMARY ANSWER Although there was no overall association between diabetes and age at menopause, our study suggests that early-onset diabetes may accelerate menopause. WHAT IS KNOWN ALREADY Today, more women of childbearing age are being diagnosed with diabetes, but little is known about the impact of diabetes on reproductive health. STUDY DESIGN, SIZE, DURATION We investigated the impact of diabetes on age at natural menopause (ANM) in 258 898 women from the European Prospective Investigation into Cancer and Nutrition (EPIC), enrolled between 1992 and 2000. PARTICIPANTS/MATERIALS, SETTING, METHODS Determinant and outcome information was obtained through questionnaires. Time-dependent Cox regression analyses were used to estimate the associations of diabetes and age at diabetes diagnosis with ANM, stratified by center and adjusted for age, smoking, reproductive and diabetes risk factors and with age from birth to menopause or censoring as the underlying time scale. MAIN RESULTS AND THE ROLE OF CHANCE Overall, no association between diabetes and ANM was found (hazard ratio (HR) = 0.94; 95% confidence interval (CI) 0.89-1.01). However, women with diabetes before the age of 20 years had an earlier menopause (10-20 years: HR = 1.43; 95% CI 1.02-2.01,
KW - age at natural menopause
KW - cox proportional hazards analyses
KW - diabetes
KW - time-dependent modeling
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U2 - 10.1093/humrep/dev054
DO - 10.1093/humrep/dev054
M3 - Article
C2 - 25779698
AN - SCOPUS:84939610963
VL - 30
SP - 1491
EP - 1498
JO - Human Reproduction
JF - Human Reproduction
SN - 0268-1161
IS - 6
ER -