Diabetes and risk of Parkinson's disease: A systematic review and meta-analysis

Emanuele Cereda, Michela Barichella, Carlo Pedrolli, Catherine Klersy, Erica Cassani, Riccardo Caccialanza, Gianni Pezzoli

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - Diabetes has been associated with chronic neurodegeneration.We performed a systematic review and meta-analysis to assess the relationship between pre-existing diabetes and Parkinson's disease (PD). RESEARCH DESIGNANDMETHODS - Original articles in English published up to 10 May 2011 were searched for in electronic databases (PubMed, Embase, and Scopus) and by reviewing references of eligible articles. Prospective cohort and case-control studies providing risk and precision estimates relating to pre-existing diabetes and PD were considered eligible. RESULTS - Nine studies/1,947 citations (cohort, N = 4; case-control, N = 5) fulfilled inclusion criteria for meta-analysis. In prospective studies, the onset of diabetes before onset of PD was found to be a risk factor for future PD (relative risk [RR] = 1.37 [95%CI 1.21-1.55]; P

Original languageEnglish
Pages (from-to)2614-2623
Number of pages10
JournalDiabetes Care
Volume34
Issue number12
DOIs
Publication statusPublished - Dec 2011

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Advanced and Specialised Nursing

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