TY - JOUR
T1 - Diabetes complications and their potential prevention
T2 - Aldose reductase inhibition and other approaches
AU - Costantino, Luca
AU - Rastelli, Giulio
AU - Vianello, Paola
AU - Cignarella, Giorgio
AU - Barlocco, Daniela
PY - 1999
Y1 - 1999
N2 - Despite recent advances both in the chemistry and molecular pharmacology of antidiabetic drugs, diabetes still remains a life-threatening disease, which tends to spread all over the world. The clinical profile of diabetic subjects is often worsened by the presence of several long-term complications, namely neuropathy, nephropathy, retinopathy, and cataract. Several attempts have been made to prevent or at least to delay them. The most relevant are reported in this review, including the development of compounds acting as aldose reductase inhibitors, anti-advanced glycation end- product drugs, free radical scavengers, vasoactive agents, essential fatty acid supplementation, and neurotropic growth factors.
AB - Despite recent advances both in the chemistry and molecular pharmacology of antidiabetic drugs, diabetes still remains a life-threatening disease, which tends to spread all over the world. The clinical profile of diabetic subjects is often worsened by the presence of several long-term complications, namely neuropathy, nephropathy, retinopathy, and cataract. Several attempts have been made to prevent or at least to delay them. The most relevant are reported in this review, including the development of compounds acting as aldose reductase inhibitors, anti-advanced glycation end- product drugs, free radical scavengers, vasoactive agents, essential fatty acid supplementation, and neurotropic growth factors.
KW - Advanced glycation end-products (AGEs)
KW - Aldose reductase inhibitors (ARIs)
KW - Diabetes complications
KW - Oxidative stress
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U2 - 10.1002/(SICI)1098-1128(199901)19:1<3::AID-MED2>3.0.CO;2-7
DO - 10.1002/(SICI)1098-1128(199901)19:1<3::AID-MED2>3.0.CO;2-7
M3 - Article
C2 - 9918192
AN - SCOPUS:0032959371
VL - 19
SP - 3
EP - 23
JO - Medicinal Research Reviews
JF - Medicinal Research Reviews
SN - 0198-6325
IS - 1
ER -