Diabetes insipidus and increased serum levels of leptin and lactate-dehydrogenase (LDH) in an adolescent boy with a primary intracranial germinoma. Case Report and an endocrinological revaluation of literature

Carlo Carella, M. Rotondi, A. Del Buono, A. M. Sinisi, M. L. Del Basso De Caro, C. M. Mone, L. Vizioli, F. Sorvillo, G. Mazziotti, A. Bellastella

Research output: Contribution to journalArticle

Abstract

A 16-year-old boy presented with a four-month history of polyuria-polydipsia and a diplopia which had reverted after treatment. The neuroimaging studies performed had been strongly suggestive of an optic nerve glioma, while endocrinological investigation (β-hCG 420 IU/L) has lead to the correct diagnosis later confirmed at the immunohystochemical analysis performed at biopsy. The high serum level of hCG was unaffected by bromocriptine nor octreotide, while the PRL level (80.0 μg/L) was reduced only by bromocriptine. Among the several tumor markers which may be secreted by such lesions, ours is the first reported case of an elevation of serum LDH for a primary intracranial germinoma. Moreover, the elevated value of serum leptin reported by us might be due to the insensitivity of the hypothalamic structures to endogenous leptin.

Original languageEnglish
Pages (from-to)558-561
Number of pages4
JournalJournal of Endocrinological Investigation
Volume22
Issue number7
Publication statusPublished - 1999

Keywords

  • Cerebral tumor
  • Chorionic gonadotropin
  • Intracranial germinoma
  • Lactate dehydrogenase
  • Leptin

ASJC Scopus subject areas

  • Endocrinology

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