TY - JOUR
T1 - Diabetes mellitus and cancer risk in a network of case-control studies
AU - Bosetti, Cristina
AU - Rosato, Valentina
AU - Polesel, Jerry
AU - Levi, Fabio
AU - Talamini, Renato
AU - Montella, Maurizio
AU - Negri, Eva
AU - Tavani, Alessandra
AU - Zucchetto, Antonella
AU - Franceschi, Silvia
AU - Corrao, Giovanni
AU - Vecchia, Carlo La
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Diabetes has been associated to the risk of a few cancer sites, though quantification of this association in various populations remains open to discussion. We analyzed the relation between diabetes and the risk of various cancers in an integrated series of case-control studies conducted in Italy and Switzerland between 1991 and 2009. The studies included 1,468 oral and pharyngeal, 505 esophageal, 230 gastric, 2,390 colorectal, 185 liver, 326 pancreatic, 852 laryngeal, 3,034 breast, 607 endometrial, 1,031 ovarian, 1,294 prostate, and 767 renal cell cancer cases and 12,060 hospital controls. The multivariate odds ratios (OR) for subjects with diabetes as compared to those withoutadjusted for major identified confounding factors for the cancers considered through logistic regression modelswere significantly elevated for cancers of the oral cavity/pharynx (OR = 1.58), esophagus (OR = 2.52), colorectum (OR = 1.23), liver (OR = 3.52), pancreas (OR = 3.32), postmenopausal breast (OR = 1.76), and endometrium (OR = 1.70). For cancers of the oral cavity, esophagus, colorectum, liver, and postmenopausal breast, the excess risk persisted over 10 yr since diagnosis of diabetes. Our data confirm and further quantify the association of diabetes with colorectal, liver, pancreatic, postmenopausal breast, and endometrial cancer and suggest forthe first time that diabetes may also increase the risk of oral/pharyngeal and esophageal cancer.
AB - Diabetes has been associated to the risk of a few cancer sites, though quantification of this association in various populations remains open to discussion. We analyzed the relation between diabetes and the risk of various cancers in an integrated series of case-control studies conducted in Italy and Switzerland between 1991 and 2009. The studies included 1,468 oral and pharyngeal, 505 esophageal, 230 gastric, 2,390 colorectal, 185 liver, 326 pancreatic, 852 laryngeal, 3,034 breast, 607 endometrial, 1,031 ovarian, 1,294 prostate, and 767 renal cell cancer cases and 12,060 hospital controls. The multivariate odds ratios (OR) for subjects with diabetes as compared to those withoutadjusted for major identified confounding factors for the cancers considered through logistic regression modelswere significantly elevated for cancers of the oral cavity/pharynx (OR = 1.58), esophagus (OR = 2.52), colorectum (OR = 1.23), liver (OR = 3.52), pancreas (OR = 3.32), postmenopausal breast (OR = 1.76), and endometrium (OR = 1.70). For cancers of the oral cavity, esophagus, colorectum, liver, and postmenopausal breast, the excess risk persisted over 10 yr since diagnosis of diabetes. Our data confirm and further quantify the association of diabetes with colorectal, liver, pancreatic, postmenopausal breast, and endometrial cancer and suggest forthe first time that diabetes may also increase the risk of oral/pharyngeal and esophageal cancer.
UR - http://www.scopus.com/inward/record.url?scp=84863636872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863636872&partnerID=8YFLogxK
U2 - 10.1080/01635581.2012.676141
DO - 10.1080/01635581.2012.676141
M3 - Article
C2 - 22519904
AN - SCOPUS:84863636872
VL - 64
SP - 643
EP - 651
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 5
ER -