Diabetes mellitus and ischemic heart disease: The role of ion channels

Paolo Severino, Andrea D’Amato, Lucrezia Netti, Mariateresa Pucci, Marialaura De Marchis, Raffaele Palmirotta, Maurizio Volterrani, Massimo Mancone, Francesco Fedele

Research output: Contribution to journalReview article

Abstract

Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic patients have mainly coronary stenosis obstructing blood flow to the myocardium; others present with coronary microvascular disease with an absence of plaques in the epicardial vessels. Ion channels acting in the cross-talk between the myocardial energy state and coronary blood flow may play a role in the pathophysiology of IHD in diabetic patients. In particular, some genetic variants for ATP-dependent potassium channels seem to be involved in the determinism of IHD.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume19
Issue number3
DOIs
Publication statusPublished - Mar 10 2018

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Keywords

  • Coronary blood flow
  • Diabetes mellitus
  • Ion channels
  • Ischemic heart disease

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Severino, P., D’Amato, A., Netti, L., Pucci, M., De Marchis, M., Palmirotta, R., Volterrani, M., Mancone, M., & Fedele, F. (2018). Diabetes mellitus and ischemic heart disease: The role of ion channels. International Journal of Molecular Sciences, 19(3). https://doi.org/10.3390/ijms19030802