Diabetes mellitus and the risk of bladder cancer: An Italian case-control study

F. Turati, J. Polesel, M. Di Maso, M. Montella, M. Libra, M. Grimaldi, A. Tavani, D. Serraino, C. La Vecchia, C. Bosetti

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetes mellitus has been associated with an increased risk of bladder cancer, although the evidence is still open to discussion.Methods:We examined this association using data from a multicentre Italian case-control study, conducted between 2003 and 2014 on 690 bladder cancer cases and 665 frequency-matched hospital controls. Odds ratios (ORs) for diabetes were estimated by unconditional multiple logistic regression models, after allowance for major known risk factors for bladder cancer.Results:One hundred and twelve (16.2%) cases and 57 (8.6%) controls reported a diagnosis of diabetes mellitus, corresponding to a multivariate OR of 2.09 (95% confidence interval (CI): 1.46-3.01). Bladder cancer risk increased with duration of diabetes (OR 1.92 for 1--2 (OR 1.48).Conclusion:The present study provides further support of a role of diabetes in bladder cancer aetiology, although some residual confounding by tobacco, body mass index, or other unmeasured covariates may partly explain the association observed.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalBritish Journal of Cancer
Volume113
Issue number1
DOIs
Publication statusPublished - Jun 30 2015

Keywords

  • Bladder cancer
  • case-control study
  • diabetes
  • epidemiology
  • risk factor
  • transitional cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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