Diabetes mellitus and the risk of primary liver cancer

Carlo L A Vecchia, Eva Negri, Adriano Decarli, Silvia Franceschi

Research output: Contribution to journalArticle


The relationship between diabetes mellitus and primary liver cancer was investigated in a case-control study conducted in Italy between 1984 and 1996 on 428 cases with incident, histologically confirmed hepatocellular carcinoma, 59 with gallbladder and bile duct cancer, and 1,502 control subjects in the hospital for acute non-neoplastic diseases. Sixty-four cases of hepatocellular carcinoma vs. 87 controls reported a history of diabetes, corresponding to an odds ratio (OR) of 2.3 after allowance for age, sex and area of residence, and of 2.1 [95% confidence interval (CI)= 1.4-3.2] after further allowance for alcohol and tobacco consumption, history of hepatitis and liver cirrhosis, body mass index and history of liver cancer in first- degree relatives. The ORs were similar both for subjects diagnosed with diabetes below age 45, who most likely had insulin-dependent diabetes, and for those diagnosed later, who were likelier to have non-insulin-dependent diabetes. The OR was 2.3 for subjects whose diabetes was diagnosed

Original languageEnglish
Pages (from-to)204-207
Number of pages4
JournalInternational Journal of Cancer
Issue number2
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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