Diabetes mellitus as risk factor for atrial fibrillation hospitalization: Incidence and outcomes over nine years in a region of Northern Italy

Lidia Staszewsky, Laura Cortesi, Marta Baviera, Mauro Tettamanti, Irene Marzona, Alessandro Nobili, Ida Fortino, Angela Bortolotti, Luca Merlino, Marcello Disertori, Roberto Latini, Maria Carla Roncaglioni

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: Diabetes mellitus (DM) and atrial fibrillation (AF) are worldwide public health challenges and major causes of death and cardiovascular events. The association between DM and AF is controversial in literature and data on outcomes of individuals with both diseases have not been evaluated in population studies. We tested the hypothesis that DM is independently associated to AF hospitalization and assessed the risk of stroke and mortality in people with both conditions. Methods: We conducted a population-based cohort-study of DM patients and their corresponding controls identified in a administrative health database of the Lombardy Region. Both cohorts were followed for nine years. A multivariable Cox proportional-hazards-regression model was used to estimate the hazard ratio (HR) for first hospitalization for AF and for clinical outcomes. Results: Out of 9,061,258 residents, 285,428 (3.14%) DM subjects were identified, mean age 65.8 ± 15 years, 49% were women. The cumulative incidence of AF in DM was 10.4% vs. 7.4% in non-DM. DM was a risk factor for AF (HR 1.32, 95% CI 1.30-1.34; p

Original languageEnglish
Pages (from-to)476-484
Number of pages9
JournalDiabetes Research and Clinical Practice
Volume109
Issue number3
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Atrial fibrillation
  • Diabetes mellitus
  • Mortality
  • Population-based cohort study
  • Stroke

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

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