Diabetes mellitus, cachexia and obesity in heart failure: Rationale and design of the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF)

Stephan von Haehling, Mitja Lainscak, Wolfram Doehner, Piotr Ponikowski, Giuseppe Rosano, Jens Jordan, Piotr Rozentryt, Mathias Rauchhaus, Rostislav Karpov, Vsevolod Tkachuk, Yelena Parfyonova, Andrey Y. Zaritskey, Eugeniy V. Shlyakhto, John G. Cleland, Stefan D. Anker

Research output: Contribution to journalArticle

Abstract

Background: Chronic heart failure (CHF) is increasing in prevalence. Patients with CHF usually have co-morbid conditions, but these have been subjected to little research and consequently there is a paucity of guidance on how to manage them. Obesity and diabetes mellitus are common antecedents of CHF and often complicate management and influence outcome. Cachexia is an ominous and often missed sign in patients with CHF. Methods: This manuscript describes the rationale and the design of Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF), a prospective, multicentre, multinational, longitudinal, pathophysiological evaluation study, which is being conducted in 11 centres across six countries in the European Union and in Russia. We aim to recruit >1,600 patients with CHF due to various common aetiologies, irrespective of left ventricular ejection fraction, and with or without co-morbidities at study entry. In addition, >300 patients with type 2 diabetes mellitus without CHF and >150 healthy subjects will serve as control groups. Participants will be systematically investigated at annual intervals for up to 48 months. Additional investigations focusing on cellular and subcellular mechanisms, adipose and skeletal muscle tissue, and in endothelial progenitor cells will be performed in selected subgroups. Conclusions: SICA-HF will provide insights into common co-morbidities in CHF with a specific emphasis on diabetes mellitus and body mass. This will provide a more thorough pathophysiological understanding of the complexity of CHF that will help develop therapies tailored to manage specific co-morbidities.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalJournal of Cachexia, Sarcopenia and Muscle
Volume1
Issue number2
DOIs
Publication statusPublished - 2010

Keywords

  • Cachexia
  • Diabetes mellitus
  • Heart failure
  • Obesity
  • Pathophysiology

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physiology (medical)

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    von Haehling, S., Lainscak, M., Doehner, W., Ponikowski, P., Rosano, G., Jordan, J., Rozentryt, P., Rauchhaus, M., Karpov, R., Tkachuk, V., Parfyonova, Y., Zaritskey, A. Y., Shlyakhto, E. V., Cleland, J. G., & Anker, S. D. (2010). Diabetes mellitus, cachexia and obesity in heart failure: Rationale and design of the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF). Journal of Cachexia, Sarcopenia and Muscle, 1(2), 187-194. https://doi.org/10.1007/s13539-010-0013-3