Diabetes, smoking, alcohol use, and family history of cancer as risk factors for pancreatic neuroendocrine tumors

A systematic review and meta-analysis

Sven Petter Haugvik, Per Hedenström, Emilie Korsæth, Roberto Valente, Alastair Hayes, Darko Siuka, Patrick Maisonneuve, Ivar Prydz Gladhaug, Björn Lindkvist, Gabriele Capurso

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background and Aims: Risk factors for pancreatic neuroendocrine tumors (PNETs) are not well understood. The aim of this systematic review was to assess if diabetes mellitus, smoking, alcohol use, and family history of cancer are risk factors for PNETs. Methods: MEDLINE and abstracts from the European and North American Neuroendocrine Tumor Societies (ENETS and NANETS) were searched for studies published until October 2013. Eligible studies were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: Five studies evaluating 4 individual populations were included (study accrual period 2000-2011) into the meta-analysis, involving 827 cases (range 160-309 per study) and 2,407 controls (range 233-924 per study). All studies had a case-control design and described regional series. The pooled adjusted odds ratio was 2.74 (95% CI: 1.63-4.62; p <0.01; I2 = 60.4%) for history of diabetes, 1.21 (95% CI: 0.92-1.58; p = 0.18; I2 = 45.8%) for ever smoking, 1.37 (95% CI: 0.99-1.91; p = 0.06; I2 = 0.0%) for heavy smoking, 1.09 (95% CI: 0.64-1.85; p = 0.75; I2 = 85.2%) for ever alcohol use, 2.72 (95% CI: 1.25-5.91; p = 0.01; I2 = 57.8%) for heavy alcohol use, and 2.16 (95% CI: 1.64-2.85; p <0.01; I2 = 0.0%) for first-degree family history of cancer. Conclusions: Diabetes mellitus and first-degree family history of cancer are associated with an increased risk of sporadic PNET. There was also a trend for diagnosis of sporadic PNET associated with heavy smoking. Alcohol use may be a risk factor for PNET, but there was considerable heterogeneity in the meta-analysis. These results suggest the need for a larger, homogeneous, international study for the clarification of risk factors for the occurrence of PNET.

Original languageEnglish
Pages (from-to)133-142
Number of pages10
JournalNeuroendocrinology
Volume101
Issue number2
DOIs
Publication statusPublished - May 28 2015

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Neuroendocrine Tumors
Meta-Analysis
Smoking
Alcohols
Neoplasms
Diabetes Mellitus
MEDLINE
Odds Ratio
Population

Keywords

  • Epidemiology
  • Meta-analysis
  • Neuroendocrine tumor
  • Pancreatic neuroendocrine tumor
  • Risk factor
  • Sporadic pancreatic neuroendocrine tumor

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Diabetes, smoking, alcohol use, and family history of cancer as risk factors for pancreatic neuroendocrine tumors : A systematic review and meta-analysis. / Haugvik, Sven Petter; Hedenström, Per; Korsæth, Emilie; Valente, Roberto; Hayes, Alastair; Siuka, Darko; Maisonneuve, Patrick; Gladhaug, Ivar Prydz; Lindkvist, Björn; Capurso, Gabriele.

In: Neuroendocrinology, Vol. 101, No. 2, 28.05.2015, p. 133-142.

Research output: Contribution to journalArticle

Haugvik, SP, Hedenström, P, Korsæth, E, Valente, R, Hayes, A, Siuka, D, Maisonneuve, P, Gladhaug, IP, Lindkvist, B & Capurso, G 2015, 'Diabetes, smoking, alcohol use, and family history of cancer as risk factors for pancreatic neuroendocrine tumors: A systematic review and meta-analysis', Neuroendocrinology, vol. 101, no. 2, pp. 133-142. https://doi.org/10.1159/000375164
Haugvik, Sven Petter ; Hedenström, Per ; Korsæth, Emilie ; Valente, Roberto ; Hayes, Alastair ; Siuka, Darko ; Maisonneuve, Patrick ; Gladhaug, Ivar Prydz ; Lindkvist, Björn ; Capurso, Gabriele. / Diabetes, smoking, alcohol use, and family history of cancer as risk factors for pancreatic neuroendocrine tumors : A systematic review and meta-analysis. In: Neuroendocrinology. 2015 ; Vol. 101, No. 2. pp. 133-142.
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abstract = "Background and Aims: Risk factors for pancreatic neuroendocrine tumors (PNETs) are not well understood. The aim of this systematic review was to assess if diabetes mellitus, smoking, alcohol use, and family history of cancer are risk factors for PNETs. Methods: MEDLINE and abstracts from the European and North American Neuroendocrine Tumor Societies (ENETS and NANETS) were searched for studies published until October 2013. Eligible studies were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: Five studies evaluating 4 individual populations were included (study accrual period 2000-2011) into the meta-analysis, involving 827 cases (range 160-309 per study) and 2,407 controls (range 233-924 per study). All studies had a case-control design and described regional series. The pooled adjusted odds ratio was 2.74 (95{\%} CI: 1.63-4.62; p <0.01; I2 = 60.4{\%}) for history of diabetes, 1.21 (95{\%} CI: 0.92-1.58; p = 0.18; I2 = 45.8{\%}) for ever smoking, 1.37 (95{\%} CI: 0.99-1.91; p = 0.06; I2 = 0.0{\%}) for heavy smoking, 1.09 (95{\%} CI: 0.64-1.85; p = 0.75; I2 = 85.2{\%}) for ever alcohol use, 2.72 (95{\%} CI: 1.25-5.91; p = 0.01; I2 = 57.8{\%}) for heavy alcohol use, and 2.16 (95{\%} CI: 1.64-2.85; p <0.01; I2 = 0.0{\%}) for first-degree family history of cancer. Conclusions: Diabetes mellitus and first-degree family history of cancer are associated with an increased risk of sporadic PNET. There was also a trend for diagnosis of sporadic PNET associated with heavy smoking. Alcohol use may be a risk factor for PNET, but there was considerable heterogeneity in the meta-analysis. These results suggest the need for a larger, homogeneous, international study for the clarification of risk factors for the occurrence of PNET.",
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AU - Korsæth, Emilie

AU - Valente, Roberto

AU - Hayes, Alastair

AU - Siuka, Darko

AU - Maisonneuve, Patrick

AU - Gladhaug, Ivar Prydz

AU - Lindkvist, Björn

AU - Capurso, Gabriele

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N2 - Background and Aims: Risk factors for pancreatic neuroendocrine tumors (PNETs) are not well understood. The aim of this systematic review was to assess if diabetes mellitus, smoking, alcohol use, and family history of cancer are risk factors for PNETs. Methods: MEDLINE and abstracts from the European and North American Neuroendocrine Tumor Societies (ENETS and NANETS) were searched for studies published until October 2013. Eligible studies were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: Five studies evaluating 4 individual populations were included (study accrual period 2000-2011) into the meta-analysis, involving 827 cases (range 160-309 per study) and 2,407 controls (range 233-924 per study). All studies had a case-control design and described regional series. The pooled adjusted odds ratio was 2.74 (95% CI: 1.63-4.62; p <0.01; I2 = 60.4%) for history of diabetes, 1.21 (95% CI: 0.92-1.58; p = 0.18; I2 = 45.8%) for ever smoking, 1.37 (95% CI: 0.99-1.91; p = 0.06; I2 = 0.0%) for heavy smoking, 1.09 (95% CI: 0.64-1.85; p = 0.75; I2 = 85.2%) for ever alcohol use, 2.72 (95% CI: 1.25-5.91; p = 0.01; I2 = 57.8%) for heavy alcohol use, and 2.16 (95% CI: 1.64-2.85; p <0.01; I2 = 0.0%) for first-degree family history of cancer. Conclusions: Diabetes mellitus and first-degree family history of cancer are associated with an increased risk of sporadic PNET. There was also a trend for diagnosis of sporadic PNET associated with heavy smoking. Alcohol use may be a risk factor for PNET, but there was considerable heterogeneity in the meta-analysis. These results suggest the need for a larger, homogeneous, international study for the clarification of risk factors for the occurrence of PNET.

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