Diabetic Cardiomyopathy: Definition, Diagnosis, and Therapeutic Implications

Stefania Paolillo, Fabio Marsico, Maria Prastaro, Francesco Renga, Luca Esposito, Fabiana De Martino, Pierfrancesco Di Napoli, Immacolata Esposito, Antonio Ambrosio, Monica Ianniruberto, Rosa Mennella, Roberta Paolillo, Paola Gargiulo

Research output: Contribution to journalReview articlepeer-review


A strict bidirectional relationship exists between diabetes mellitus and heart failure. Diabetic cardiomyopathy is a specific cardiac manifestation of patients with diabetes characterized by left ventricular hypertrophy and diastolic dysfunction in the early phase up to overt heart failure with reduced systolic function in the advanced stages. The pathogenesis of this condition is multifactorial and recognizes as main promoting factors the presence of insulin resistance and hyperglycemia. Diabetic cardiomyopathy exerts a negative prognostic impact in affected patients and no target treatments are currently available. More efforts are needed to better define the diagnostic and therapeutic approach in this specific setting.

Original languageEnglish
Pages (from-to)341-347
Number of pages7
JournalHeart Failure Clinics
Issue number3
Publication statusPublished - Jul 2019


  • Diabetes mellitus
  • Diabetic cardiomyopathy
  • Diastolic dysfunction
  • Heart failure
  • Systolic dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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