TY - JOUR
T1 - Diabetic Cardiomyopathy
T2 - Definition, Diagnosis, and Therapeutic Implications
AU - Paolillo, Stefania
AU - Marsico, Fabio
AU - Prastaro, Maria
AU - Renga, Francesco
AU - Esposito, Luca
AU - De Martino, Fabiana
AU - Di Napoli, Pierfrancesco
AU - Esposito, Immacolata
AU - Ambrosio, Antonio
AU - Ianniruberto, Monica
AU - Mennella, Rosa
AU - Paolillo, Roberta
AU - Gargiulo, Paola
PY - 2019/7
Y1 - 2019/7
N2 - A strict bidirectional relationship exists between diabetes mellitus and heart failure. Diabetic cardiomyopathy is a specific cardiac manifestation of patients with diabetes characterized by left ventricular hypertrophy and diastolic dysfunction in the early phase up to overt heart failure with reduced systolic function in the advanced stages. The pathogenesis of this condition is multifactorial and recognizes as main promoting factors the presence of insulin resistance and hyperglycemia. Diabetic cardiomyopathy exerts a negative prognostic impact in affected patients and no target treatments are currently available. More efforts are needed to better define the diagnostic and therapeutic approach in this specific setting.
AB - A strict bidirectional relationship exists between diabetes mellitus and heart failure. Diabetic cardiomyopathy is a specific cardiac manifestation of patients with diabetes characterized by left ventricular hypertrophy and diastolic dysfunction in the early phase up to overt heart failure with reduced systolic function in the advanced stages. The pathogenesis of this condition is multifactorial and recognizes as main promoting factors the presence of insulin resistance and hyperglycemia. Diabetic cardiomyopathy exerts a negative prognostic impact in affected patients and no target treatments are currently available. More efforts are needed to better define the diagnostic and therapeutic approach in this specific setting.
KW - Diabetes mellitus
KW - Diabetic cardiomyopathy
KW - Diastolic dysfunction
KW - Heart failure
KW - Systolic dysfunction
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U2 - 10.1016/j.hfc.2019.02.003
DO - 10.1016/j.hfc.2019.02.003
M3 - Review article
C2 - 31079692
AN - SCOPUS:85063862252
VL - 15
SP - 341
EP - 347
JO - Heart Failure Clinics
JF - Heart Failure Clinics
SN - 1551-7136
IS - 3
ER -