Diabetic Cardiomyopathy: Definition, Diagnosis, and Therapeutic Implications

Stefania Paolillo; Fabio Marsico; Maria Prastaro; Francesco Renga; Luca Esposito; Fabiana De Martino; Pierfrancesco Di Napoli; Immacolata Esposito; Antonio Ambrosio; Monica Ianniruberto; Rosa Mennella; Roberta Paolillo; Paola Gargiulo

doi:10.1016/j.hfc.2019.02.003

Diabetic Cardiomyopathy: Definition, Diagnosis, and Therapeutic Implications

Stefania Paolillo, Fabio Marsico, Maria Prastaro, Francesco Renga, Luca Esposito, Fabiana De Martino, Pierfrancesco Di Napoli, Immacolata Esposito, Antonio Ambrosio, Monica Ianniruberto, Rosa Mennella, Roberta Paolillo, Paola Gargiulo

Research output: Contribution to journal › Review article › peer-review

Abstract

A strict bidirectional relationship exists between diabetes mellitus and heart failure. Diabetic cardiomyopathy is a specific cardiac manifestation of patients with diabetes characterized by left ventricular hypertrophy and diastolic dysfunction in the early phase up to overt heart failure with reduced systolic function in the advanced stages. The pathogenesis of this condition is multifactorial and recognizes as main promoting factors the presence of insulin resistance and hyperglycemia. Diabetic cardiomyopathy exerts a negative prognostic impact in affected patients and no target treatments are currently available. More efforts are needed to better define the diagnostic and therapeutic approach in this specific setting.

Original language	English
Pages (from-to)	341-347
Number of pages	7
Journal	Heart Failure Clinics
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.hfc.2019.02.003
Publication status	Published - Jul 2019

Keywords

Diabetes mellitus
Diabetic cardiomyopathy
Diastolic dysfunction
Heart failure
Systolic dysfunction

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.hfc.2019.02.003

Cite this

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title = "Diabetic Cardiomyopathy: Definition, Diagnosis, and Therapeutic Implications",

abstract = "A strict bidirectional relationship exists between diabetes mellitus and heart failure. Diabetic cardiomyopathy is a specific cardiac manifestation of patients with diabetes characterized by left ventricular hypertrophy and diastolic dysfunction in the early phase up to overt heart failure with reduced systolic function in the advanced stages. The pathogenesis of this condition is multifactorial and recognizes as main promoting factors the presence of insulin resistance and hyperglycemia. Diabetic cardiomyopathy exerts a negative prognostic impact in affected patients and no target treatments are currently available. More efforts are needed to better define the diagnostic and therapeutic approach in this specific setting.",

keywords = "Diabetes mellitus, Diabetic cardiomyopathy, Diastolic dysfunction, Heart failure, Systolic dysfunction",

author = "Stefania Paolillo and Fabio Marsico and Maria Prastaro and Francesco Renga and Luca Esposito and {De Martino}, Fabiana and {Di Napoli}, Pierfrancesco and Immacolata Esposito and Antonio Ambrosio and Monica Ianniruberto and Rosa Mennella and Roberta Paolillo and Paola Gargiulo",

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T2 - Definition, Diagnosis, and Therapeutic Implications

AU - Paolillo, Stefania

AU - Marsico, Fabio

AU - Prastaro, Maria

AU - Renga, Francesco

AU - Esposito, Luca

AU - De Martino, Fabiana

AU - Di Napoli, Pierfrancesco

AU - Esposito, Immacolata

AU - Ambrosio, Antonio

AU - Ianniruberto, Monica

AU - Mennella, Rosa

AU - Paolillo, Roberta

AU - Gargiulo, Paola

PY - 2019/7

Y1 - 2019/7

N2 - A strict bidirectional relationship exists between diabetes mellitus and heart failure. Diabetic cardiomyopathy is a specific cardiac manifestation of patients with diabetes characterized by left ventricular hypertrophy and diastolic dysfunction in the early phase up to overt heart failure with reduced systolic function in the advanced stages. The pathogenesis of this condition is multifactorial and recognizes as main promoting factors the presence of insulin resistance and hyperglycemia. Diabetic cardiomyopathy exerts a negative prognostic impact in affected patients and no target treatments are currently available. More efforts are needed to better define the diagnostic and therapeutic approach in this specific setting.

AB - A strict bidirectional relationship exists between diabetes mellitus and heart failure. Diabetic cardiomyopathy is a specific cardiac manifestation of patients with diabetes characterized by left ventricular hypertrophy and diastolic dysfunction in the early phase up to overt heart failure with reduced systolic function in the advanced stages. The pathogenesis of this condition is multifactorial and recognizes as main promoting factors the presence of insulin resistance and hyperglycemia. Diabetic cardiomyopathy exerts a negative prognostic impact in affected patients and no target treatments are currently available. More efforts are needed to better define the diagnostic and therapeutic approach in this specific setting.

KW - Diabetes mellitus

KW - Diabetic cardiomyopathy

KW - Diastolic dysfunction

KW - Heart failure

KW - Systolic dysfunction

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Diabetic Cardiomyopathy: Definition, Diagnosis, and Therapeutic Implications

Abstract

Keywords

ASJC Scopus subject areas

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