Diabetic Papillopathy (DP): A 4-year follow-up study of 69 eyes

R. Lattanzio, F. Bandello, R. Brancato, G. Maestranzi, G. Moretti

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Abstract

Purpose. To evaluate the evolution of retinal and disk lesions in pts affected by DP. Methods. 50 pts (69 eyes) were included; 34 (68%) were females; mean age was 49.5 yrs±16.8 and mean duration of diabetes 13.2 yrs±7.8; 29 (58%) were insulin-dependent; high blood pressure coexisted in 29 (58%) pts. The lesion was bilateral in 19 (38%) pts; the optic disc involvement sectorial in 41 (59.4%) eyes. In 10/46 (21.7%) eyes in which visual field exam was performed, only a slight blind spot enlargement was observed. The coexisting diabetic retinopathy (DR) was absent in 4.3% of cases, nonproliferative in 55%, preproliferative in 34.8%, proliferative in 5.9%. Results. We followed 38/50 pts (54 eyes) for a mean period of 52.7 mos±34.1. The initial visual acuity was 0.67±0.30 and the final 0.58±0.32. The mean time between diagnosis and regression of DP was 6.2 mos±3.4. In 16/54 eyes (29.6%) DP reappeared during the follow-up: in 18.5% in the same sector and in 11.1% in different sectors of optic disc. With regard to the evolution of DR, 46.1% of the eyes showed a progression of retinal lesions during the follow-up; in 10.7% of cases a proliferative stage occurred. Conclusions. DP turned out to be associated with preproliferative DR in a high percentage of cases. It is possible to speculate that DP is a consequence of lesions localized at the level of the third retinal capillary layer; the characteristics of this network could justify a specific involvement in cases of impaired blood flow, as typically present in the preproliferative stage of DR.

Original languageEnglish
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
Publication statusPublished - Feb 15 1996

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Diabetic Retinopathy
Optic Disk
Visual Field Tests
Visual Acuity
Insulin
Hypertension

ASJC Scopus subject areas

  • Ophthalmology

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Diabetic Papillopathy (DP) : A 4-year follow-up study of 69 eyes. / Lattanzio, R.; Bandello, F.; Brancato, R.; Maestranzi, G.; Moretti, G.

In: Investigative Ophthalmology and Visual Science, Vol. 37, No. 3, 15.02.1996.

Research output: Contribution to journalArticle

Lattanzio, R. ; Bandello, F. ; Brancato, R. ; Maestranzi, G. ; Moretti, G. / Diabetic Papillopathy (DP) : A 4-year follow-up study of 69 eyes. In: Investigative Ophthalmology and Visual Science. 1996 ; Vol. 37, No. 3.
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abstract = "Purpose. To evaluate the evolution of retinal and disk lesions in pts affected by DP. Methods. 50 pts (69 eyes) were included; 34 (68{\%}) were females; mean age was 49.5 yrs±16.8 and mean duration of diabetes 13.2 yrs±7.8; 29 (58{\%}) were insulin-dependent; high blood pressure coexisted in 29 (58{\%}) pts. The lesion was bilateral in 19 (38{\%}) pts; the optic disc involvement sectorial in 41 (59.4{\%}) eyes. In 10/46 (21.7{\%}) eyes in which visual field exam was performed, only a slight blind spot enlargement was observed. The coexisting diabetic retinopathy (DR) was absent in 4.3{\%} of cases, nonproliferative in 55{\%}, preproliferative in 34.8{\%}, proliferative in 5.9{\%}. Results. We followed 38/50 pts (54 eyes) for a mean period of 52.7 mos±34.1. The initial visual acuity was 0.67±0.30 and the final 0.58±0.32. The mean time between diagnosis and regression of DP was 6.2 mos±3.4. In 16/54 eyes (29.6{\%}) DP reappeared during the follow-up: in 18.5{\%} in the same sector and in 11.1{\%} in different sectors of optic disc. With regard to the evolution of DR, 46.1{\%} of the eyes showed a progression of retinal lesions during the follow-up; in 10.7{\%} of cases a proliferative stage occurred. Conclusions. DP turned out to be associated with preproliferative DR in a high percentage of cases. It is possible to speculate that DP is a consequence of lesions localized at the level of the third retinal capillary layer; the characteristics of this network could justify a specific involvement in cases of impaired blood flow, as typically present in the preproliferative stage of DR.",
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AU - Moretti, G.

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N2 - Purpose. To evaluate the evolution of retinal and disk lesions in pts affected by DP. Methods. 50 pts (69 eyes) were included; 34 (68%) were females; mean age was 49.5 yrs±16.8 and mean duration of diabetes 13.2 yrs±7.8; 29 (58%) were insulin-dependent; high blood pressure coexisted in 29 (58%) pts. The lesion was bilateral in 19 (38%) pts; the optic disc involvement sectorial in 41 (59.4%) eyes. In 10/46 (21.7%) eyes in which visual field exam was performed, only a slight blind spot enlargement was observed. The coexisting diabetic retinopathy (DR) was absent in 4.3% of cases, nonproliferative in 55%, preproliferative in 34.8%, proliferative in 5.9%. Results. We followed 38/50 pts (54 eyes) for a mean period of 52.7 mos±34.1. The initial visual acuity was 0.67±0.30 and the final 0.58±0.32. The mean time between diagnosis and regression of DP was 6.2 mos±3.4. In 16/54 eyes (29.6%) DP reappeared during the follow-up: in 18.5% in the same sector and in 11.1% in different sectors of optic disc. With regard to the evolution of DR, 46.1% of the eyes showed a progression of retinal lesions during the follow-up; in 10.7% of cases a proliferative stage occurred. Conclusions. DP turned out to be associated with preproliferative DR in a high percentage of cases. It is possible to speculate that DP is a consequence of lesions localized at the level of the third retinal capillary layer; the characteristics of this network could justify a specific involvement in cases of impaired blood flow, as typically present in the preproliferative stage of DR.

AB - Purpose. To evaluate the evolution of retinal and disk lesions in pts affected by DP. Methods. 50 pts (69 eyes) were included; 34 (68%) were females; mean age was 49.5 yrs±16.8 and mean duration of diabetes 13.2 yrs±7.8; 29 (58%) were insulin-dependent; high blood pressure coexisted in 29 (58%) pts. The lesion was bilateral in 19 (38%) pts; the optic disc involvement sectorial in 41 (59.4%) eyes. In 10/46 (21.7%) eyes in which visual field exam was performed, only a slight blind spot enlargement was observed. The coexisting diabetic retinopathy (DR) was absent in 4.3% of cases, nonproliferative in 55%, preproliferative in 34.8%, proliferative in 5.9%. Results. We followed 38/50 pts (54 eyes) for a mean period of 52.7 mos±34.1. The initial visual acuity was 0.67±0.30 and the final 0.58±0.32. The mean time between diagnosis and regression of DP was 6.2 mos±3.4. In 16/54 eyes (29.6%) DP reappeared during the follow-up: in 18.5% in the same sector and in 11.1% in different sectors of optic disc. With regard to the evolution of DR, 46.1% of the eyes showed a progression of retinal lesions during the follow-up; in 10.7% of cases a proliferative stage occurred. Conclusions. DP turned out to be associated with preproliferative DR in a high percentage of cases. It is possible to speculate that DP is a consequence of lesions localized at the level of the third retinal capillary layer; the characteristics of this network could justify a specific involvement in cases of impaired blood flow, as typically present in the preproliferative stage of DR.

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