Diadenosines as FHIT-ness instructors

Manuela Campiglio, Francesca Bianchi, Francesca Andriani, Gabriella Sozzi, Elda Tagliabue, Sylvie Ménard, Luca Roz

Research output: Contribution to journalArticlepeer-review


FHIT is a tumor suppressor gene that is frequently inactivated in human cancer. Although the Fhit protein is known to hydrolyze diadenosine triphosphate (Ap3A), this hydrolase activity is not required for Fhit-mediated oncosuppression. Indeed, the molecular mechanisms and the regulatory elements of Fhit oncosuppression are largely unknown. Here, we review physiological and pathological aspects of Fhit in the context of the ApnA family of signalling molecules, as well as the involvement of Fhit in apoptosis and the cell cycle in cancer models. We also discuss recent findings of novel Fhit interactions that may lead to new hypothesis about biochemical mechanisms underlying the oncosuppressor activity of this gene.

Original languageEnglish
Pages (from-to)274-281
Number of pages8
JournalJournal of Cellular Physiology
Issue number2
Publication statusPublished - Aug 2006

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology


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