Diagnosing acute encephalitis in patients with hematological disorders: caveats and pitfalls

Elisa Vegezzi; Giulia Berzero; Desiree Barbetta; Anna Amelia Colombo; Oscar Borsani; Paolo Bernasconi; Francesca Compagno; Marco Zecca; Giulia Campanini; Anna Simoncelli; Matteo Paoletti; Anna Pichiecchio; Fausto Baldanti; Enrico Brunetti; Enrico Marchioni

doi:10.1007/s13365-019-00817-z

Diagnosing acute encephalitis in patients with hematological disorders: caveats and pitfalls

Elisa Vegezzi, Giulia Berzero, Desiree Barbetta, Anna Amelia Colombo, Oscar Borsani, Paolo Bernasconi, Francesca Compagno, Marco Zecca, Giulia Campanini, Anna Simoncelli, Matteo Paoletti, Anna Pichiecchio, Fausto Baldanti, Enrico Brunetti, Enrico Marchioni

Research output: Contribution to journal › Article

Abstract

The aim of this study was to review the quality of the diagnostic work-up for acute encephalitis carried out at our center in a cohort of patients with hematological disorders. Our data showed substantial heterogeneity in investigating patients. Not all patients had their CSF tested for viruses commonly responsible for encephalitis in immunocompetent individuals (e.g., VZV, enterovirus). A blood sample for the calculation of the CSF/blood replication ratio was collected in 74% of cases. CSF cultures and immunophenotyping of CSF cells were performed in 77% and 21% of patients, respectively. A multidisciplinary consensus is needed to improve current guidelines and standardize diagnostic protocols.

Original language	English
Journal	Journal of NeuroVirology
DOIs	https://doi.org/10.1007/s13365-019-00817-z
Publication status	Accepted/In press - Jan 1 2019

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Keywords

Acute encephalitis
Diagnosis
Hematological disorders
Hematopoietic stem cell transplantation
Immunocompromised patients

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

Cite this

Vegezzi, E., Berzero, G., Barbetta, D., Colombo, A. A., Borsani, O., Bernasconi, P., Compagno, F., Zecca, M., Campanini, G., Simoncelli, A., Paoletti, M., Pichiecchio, A., Baldanti, F., Brunetti, E., & Marchioni, E. (Accepted/In press). Diagnosing acute encephalitis in patients with hematological disorders: caveats and pitfalls. Journal of NeuroVirology. https://doi.org/10.1007/s13365-019-00817-z

Diagnosing acute encephalitis in patients with hematological disorders : caveats and pitfalls. / Vegezzi, Elisa; Berzero, Giulia; Barbetta, Desiree; Colombo, Anna Amelia; Borsani, Oscar; Bernasconi, Paolo; Compagno, Francesca; Zecca, Marco ; Campanini, Giulia ; Simoncelli, Anna; Paoletti, Matteo; Pichiecchio, Anna ; Baldanti, Fausto ; Brunetti, Enrico ; Marchioni, Enrico.

In: Journal of NeuroVirology, 01.01.2019.

Research output: Contribution to journal › Article

Vegezzi, Elisa ; Berzero, Giulia ; Barbetta, Desiree ; Colombo, Anna Amelia ; Borsani, Oscar ; Bernasconi, Paolo ; Compagno, Francesca ; Zecca, Marco ; Campanini, Giulia ; Simoncelli, Anna ; Paoletti, Matteo ; Pichiecchio, Anna ; Baldanti, Fausto ; Brunetti, Enrico ; Marchioni, Enrico. / Diagnosing acute encephalitis in patients with hematological disorders : caveats and pitfalls. In: Journal of NeuroVirology. 2019.

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10.1007/s13365-019-00817-z