TY - JOUR
T1 - Diagnosing acute encephalitis in patients with hematological disorders
T2 - caveats and pitfalls
AU - Vegezzi, Elisa
AU - Berzero, Giulia
AU - Barbetta, Desiree
AU - Colombo, Anna Amelia
AU - Borsani, Oscar
AU - Bernasconi, Paolo
AU - Compagno, Francesca
AU - Zecca, Marco
AU - Campanini, Giulia
AU - Simoncelli, Anna
AU - Paoletti, Matteo
AU - Pichiecchio, Anna
AU - Baldanti, Fausto
AU - Brunetti, Enrico
AU - Marchioni, Enrico
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The aim of this study was to review the quality of the diagnostic work-up for acute encephalitis carried out at our center in a cohort of patients with hematological disorders. Our data showed substantial heterogeneity in investigating patients. Not all patients had their CSF tested for viruses commonly responsible for encephalitis in immunocompetent individuals (e.g., VZV, enterovirus). A blood sample for the calculation of the CSF/blood replication ratio was collected in 74% of cases. CSF cultures and immunophenotyping of CSF cells were performed in 77% and 21% of patients, respectively. A multidisciplinary consensus is needed to improve current guidelines and standardize diagnostic protocols.
AB - The aim of this study was to review the quality of the diagnostic work-up for acute encephalitis carried out at our center in a cohort of patients with hematological disorders. Our data showed substantial heterogeneity in investigating patients. Not all patients had their CSF tested for viruses commonly responsible for encephalitis in immunocompetent individuals (e.g., VZV, enterovirus). A blood sample for the calculation of the CSF/blood replication ratio was collected in 74% of cases. CSF cultures and immunophenotyping of CSF cells were performed in 77% and 21% of patients, respectively. A multidisciplinary consensus is needed to improve current guidelines and standardize diagnostic protocols.
KW - Acute encephalitis
KW - Diagnosis
KW - Hematological disorders
KW - Hematopoietic stem cell transplantation
KW - Immunocompromised patients
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U2 - 10.1007/s13365-019-00817-z
DO - 10.1007/s13365-019-00817-z
M3 - Article
AN - SCOPUS:85076926036
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
SN - 1355-0284
ER -