Malattia di Alzheimer: La diagnosi tra ricerca, prassi clinica ed etica

Translated title of the contribution: Diagnosing Alzheimer's disease: From research to clinical practice and ethics

Daniela Tarquini, Eugenio Pucci, Maddalena Gasparini, Silvia Zullo, Pietro Tiraboschi, Virginio Bonito, Carlo Alberto Defanti

Research output: Contribution to journalArticlepeer-review


In 2011, the so-called Dubois criteria introduced the use of biomarkers in research (in particular, brain amyloid positron emission tomography imaging and the cerebrospinal fluid levels of tau/fosfo-tau and beta-amyloid 1-42) for the early or preclinical diagnosis of Alzheimer's disease. Even so, we are looking at an increased use of these markers in clinical practice. In the 1960s, Alzheimer's disease was considered a rare form of presenile dementia, but gradually it has been recognized as the prevalent form of old-age dementia. As a consequence, what was once regarded as an inevitable outcome of old age is now recognized as a true disease. Several factors contributed to this paradigm shift, in particular a longer lifespan, new techniques of in vivo study of the central nervous system, and the pressure exerted by the pharmaceutical industry and patient groups. The current lack of disease-modifying therapies and the high incidence of mild cognitive impairment, which is a risk factor for dementia, raise a series of clinical ethical problems ranging from how diagnosis is communicated to how resources are used. This article offers a conceptual scheme through which these issues can be addressed. Copyright - Il Pensiero Scientifico Editore.

Translated title of the contributionDiagnosing Alzheimer's disease: From research to clinical practice and ethics
Original languageItalian
Pages (from-to)295-299
Number of pages5
JournalRecenti Progressi in Medicina
Issue number7-8
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Medicine(all)


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