Diagnosis and classification of autoimmune uveitis

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Uveitis is the most common ophthalmological finding in the practice of rheumatology and clinical immunology. The condition is frequently idiopathic and defined by the inflammatory status of the uvea, the part of the middle eye that includes the iris, ciliary body and choroid. Anterior uveitis involves the iris and ciliary body, while the posterior form is limited to the retina and choroid. Both forms represent indications for an urgent evaluation by an ophthalmologist as untreated cases may cause blindness. Anterior uveitis is associated with the HLA-B27 allele and is a classification criterion for seronegative arthritis forms such as ankylosing spondylitis, psoriatic arthropathy, arthritis associated with Crohn's disease and ulcerative colitis, and reactive arthritis. Posterior uveitis is associated with Behcet's disease and HLA-B51. The clinical suspicion is raised by self-reported symptoms in the case of anterior involvement and floaters for posterior uveitis while the diagnosis, in the absence of established criteria, is made by an experienced ophthalmologist.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
JournalAutoimmunity Reviews
Volume13
Issue number4-5
DOIs
Publication statusPublished - 2014

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Posterior Uveitis
Anterior Uveitis
Ciliary Body
Psoriatic Arthritis
Choroid
Uveitis
Iris
HLA-B51 Antigen
Uvea
HLA-B27 Antigen
Reactive Arthritis
Behcet Syndrome
Ankylosing Spondylitis
Rheumatology
Blindness
Allergy and Immunology
Ulcerative Colitis
Crohn Disease
Arthritis
Retina

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Diagnosis and classification of autoimmune uveitis. / Selmi, Carlo.

In: Autoimmunity Reviews, Vol. 13, No. 4-5, 2014, p. 591-594.

Research output: Contribution to journalArticle

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