TY - JOUR
T1 - Diagnosis and classification of myelodysplastic syndrome
T2 - International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts
AU - Mufti, Ghulam J.
AU - Bennett, John M.
AU - Goasguen, Jean
AU - Bain, Barbara J.
AU - Baumann, Irith
AU - Brunning, Richard
AU - Cazzola, Mario
AU - Fenaux, Pierre
AU - Germing, Ulrich
AU - Hellström-Lindberg, Eva
AU - Jinnai, Itsuro
AU - Manabe, Atsushi
AU - Matsuda, Akira
AU - Niemeyer, Charlotte M.
AU - Sanz, Guillermo
AU - Tomonaga, Masao
AU - Vallespi, Teresa
AU - Yoshimi, Ayami
PY - 2008/11
Y1 - 2008/11
N2 - The classification of myelodysplastic syndromes is based on the morphological criteria proposed by the French-American-British (FAB) and World Health Organization (WHO) groups. Accurate enumeration of blast cells, although essential for diagnosis of myelodysplastic syndrome and for assignment to prognostic groups, is often difficult, due to imprecise criteria for the morphological definition of blasts and promyelocytes. An International Working Group on Morphology of Myelodysplastic Syndrome (IWGM-MDS) of hematopathologists and hematologists expert in the field of myelodysplastic syndrome reviewed the morphological features of bone marrows from all subtypes of myelodysplastic syndrome and agreed on a set of recommendations, including recommendations for the definition and enumeration of blast cells and ring sideroblasts. It is recommended that (1) agranular or granular blast cells be defined (replacing the previous type I, II and III blasts), (2) dysplastic promyelocytes be distinguished from cytologically normal promyelocytes and from granular blast cells, (3) sufficient cells be counted to give a precise blast percentage, particularly at thresholds that are important for diagnosis or prognosis and (4) ring sideroblasts be defined as erythroblasts in which there are a minimum of 5 siderotic granules covering at least a third of the nuclear circumference. Clear definitions and a differential count of a sufficient number of cells is likely to improve precision in the diagnosis and classification of myelodysplastic syndrome. Recommendations should be applied in the context of the WHO classification.
AB - The classification of myelodysplastic syndromes is based on the morphological criteria proposed by the French-American-British (FAB) and World Health Organization (WHO) groups. Accurate enumeration of blast cells, although essential for diagnosis of myelodysplastic syndrome and for assignment to prognostic groups, is often difficult, due to imprecise criteria for the morphological definition of blasts and promyelocytes. An International Working Group on Morphology of Myelodysplastic Syndrome (IWGM-MDS) of hematopathologists and hematologists expert in the field of myelodysplastic syndrome reviewed the morphological features of bone marrows from all subtypes of myelodysplastic syndrome and agreed on a set of recommendations, including recommendations for the definition and enumeration of blast cells and ring sideroblasts. It is recommended that (1) agranular or granular blast cells be defined (replacing the previous type I, II and III blasts), (2) dysplastic promyelocytes be distinguished from cytologically normal promyelocytes and from granular blast cells, (3) sufficient cells be counted to give a precise blast percentage, particularly at thresholds that are important for diagnosis or prognosis and (4) ring sideroblasts be defined as erythroblasts in which there are a minimum of 5 siderotic granules covering at least a third of the nuclear circumference. Clear definitions and a differential count of a sufficient number of cells is likely to improve precision in the diagnosis and classification of myelodysplastic syndrome. Recommendations should be applied in the context of the WHO classification.
KW - Myeloblast
KW - Myelodysplastic syndrome
KW - Ring sideroblast
UR - http://www.scopus.com/inward/record.url?scp=55549136382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55549136382&partnerID=8YFLogxK
U2 - 10.3324/haematol.13405
DO - 10.3324/haematol.13405
M3 - Article
C2 - 18838480
AN - SCOPUS:55549136382
VL - 93
SP - 1712
EP - 1717
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 11
ER -