Diagnosis and classification of reactive arthritis

Carlo Selmi, M. Eric Gershwin

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Reactive arthritis is a form of seronegative spondyloarthritis clinically associated with inflammatory back pain, additive or migratory oligoarthritis, and extra-articular symptoms that typically follow a gastrointestinal or urogenital infection by a minimum of 1 to a maximum of 3-6. weeks. Once arthritis is observed, however, microbial tests and blood or synovial fluid cultures are negative, and only serum antibodies are detected. Reactive arthritis commonly affects young adults, most frequently white and carrying the HLA-B27 allele. The genetic susceptibility appears as necessary with only 1-15% of cases of infection developing reactive arthritis. Clinical symptoms are different from septic arthritis which manifests with fever, systemic signs of infection, and monoarthritis. The presence of large joint oligoarthritis, urogenital tract infection, and uveitis characterizes Reiter's syndrome as a clinical subtype. Ocular, skin, and heart involvement are not uncommon and may be largely variable in severity. Diagnostic criteria are based on the ACR guidelines and include rheumatological signs along with a proof of infection.

Original languageEnglish
Pages (from-to)546-549
Number of pages4
JournalAutoimmunity Reviews
Volume13
Issue number4-5
DOIs
Publication statusPublished - 2014

Fingerprint

Reactive Arthritis
Infection
Joints
HLA-B27 Antigen
Infectious Arthritis
Synovial Fluid
Uveitis
Hematologic Tests
Back Pain
Genetic Predisposition to Disease
Arthritis
Young Adult
Fever
Alleles
Guidelines
Skin
Antibodies
Serum

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Diagnosis and classification of reactive arthritis. / Selmi, Carlo; Gershwin, M. Eric.

In: Autoimmunity Reviews, Vol. 13, No. 4-5, 2014, p. 546-549.

Research output: Contribution to journalArticle

Selmi, Carlo ; Gershwin, M. Eric. / Diagnosis and classification of reactive arthritis. In: Autoimmunity Reviews. 2014 ; Vol. 13, No. 4-5. pp. 546-549.
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