Diagnosis and clinical management of neurological disorders caused by cytomegalovirus in AIDS patients

Paola Cinque, Graham M. Cleator, Thomas Weber, Philippe Monteyne, Christian Sindic, Guiseppe Gerna, Anton M. Van Loon, Paul E. Klapper

Research output: Contribution to journalArticle

Abstract

Cytomegalovirus (CMV) infections are common and severe complications of HIV infection. The virus involves the nervous system, causing encephalitis, polyradiculomyelitis and peripheral neuropathies. Due to their limited sensitivity, traditional virological approaches, such as virus isolation or antigen detection in the CSF are useful only in limited instances, e.g. CMV polyradiculopathy. The aetiological diagnosis of these disorders relies on the analysis of cerebrospinal fluid by PCR and quantitative PCR may be important to establish the extent of CNS lesions and to monitor the efficacy of antiviral treatments. CMV is susceptible to various antivirals, including ganciclovir, foscarnet and cidofovir. CMV infections of the nervous system, in particular encephalitis, however, show only a poor response to standard treatments. Drug combination treatments i.e. ganciclovir plus foscarnet, are currently under evaluation in clinical trials.

Original languageEnglish
Pages (from-to)120-132
Number of pages13
JournalJournal of NeuroVirology
Volume4
Issue number1
Publication statusPublished - 1998

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Keywords

  • CMV
  • Encephalitis
  • Foscarnet
  • Ganciclovir
  • Nervous system
  • PCR

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Cinque, P., Cleator, G. M., Weber, T., Monteyne, P., Sindic, C., Gerna, G., Van Loon, A. M., & Klapper, P. E. (1998). Diagnosis and clinical management of neurological disorders caused by cytomegalovirus in AIDS patients. Journal of NeuroVirology, 4(1), 120-132.