TY - JOUR
T1 - Diagnosis and management of primary autoimmune neutropenia in children
T2 - Insights for clinicians
AU - Farruggia, Piero
AU - Dufour, Carlo
PY - 2015
Y1 - 2015
N2 - Autoimmune neutropenia of infancy (AIN), also called primary autoimmune neutropenia, is a disease in which antibodies recognize membrane antigens of neutrophils, mostly located on immunoglobulin G (IgG) Fc receptor type 3b (FcIIIb receptor), causing their peripheral destruction. It is the most frequent type of neutropenia in children under 3-4 years of age and in most cases shows a benign, self-limited course. The diagnosis is based on evidence of indirect antineutrophil antibodies, whose detection frequently remains difficult. In this review we have analyzed the literature regarding AIN and present our personal experience in diagnosis and management.
AB - Autoimmune neutropenia of infancy (AIN), also called primary autoimmune neutropenia, is a disease in which antibodies recognize membrane antigens of neutrophils, mostly located on immunoglobulin G (IgG) Fc receptor type 3b (FcIIIb receptor), causing their peripheral destruction. It is the most frequent type of neutropenia in children under 3-4 years of age and in most cases shows a benign, self-limited course. The diagnosis is based on evidence of indirect antineutrophil antibodies, whose detection frequently remains difficult. In this review we have analyzed the literature regarding AIN and present our personal experience in diagnosis and management.
KW - autoimmune
KW - children
KW - neutropenia
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U2 - 10.1177/2040620714556642
DO - 10.1177/2040620714556642
M3 - Review article
AN - SCOPUS:84993737917
VL - 6
SP - 15
EP - 24
JO - Therapeutic Advances in Hematology
JF - Therapeutic Advances in Hematology
SN - 2040-6207
IS - 1
ER -