Diagnosis and management of primary autoimmune neutropenia in children: Insights for clinicians

Piero Farruggia, Carlo Dufour

Research output: Contribution to journalReview articlepeer-review

Abstract

Autoimmune neutropenia of infancy (AIN), also called primary autoimmune neutropenia, is a disease in which antibodies recognize membrane antigens of neutrophils, mostly located on immunoglobulin G (IgG) Fc receptor type 3b (FcIIIb receptor), causing their peripheral destruction. It is the most frequent type of neutropenia in children under 3-4 years of age and in most cases shows a benign, self-limited course. The diagnosis is based on evidence of indirect antineutrophil antibodies, whose detection frequently remains difficult. In this review we have analyzed the literature regarding AIN and present our personal experience in diagnosis and management.

Original languageEnglish
Pages (from-to)15-24
Number of pages10
JournalTherapeutic Advances in Hematology
Volume6
Issue number1
DOIs
Publication statusPublished - 2015

Keywords

  • autoimmune
  • children
  • neutropenia

ASJC Scopus subject areas

  • Hematology

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