Diagnosis and origin determination of malignant pleural effusions through the use of the breast cancer marker human mammaglobin

Silvio Roncella, Paola Ferro, Maria Cristiana Franceschini, Bartolomeo Bacigalupo, Paolo Dessanti, Massimiliano Sivori, Anna Maria Carletti, Vincenzo Fontana, Pier Aldo Canessa, Maria Pia Pistillo, Franco Fedeli

Research output: Contribution to journalArticlepeer-review

Abstract

As was reported that human mammaglobin (hMAM) may be expressed in malignant pleural effusions (PEs), we investigated the relevance of hMAM reverse-transcriptase polymerase chain reaction (RT-PCR) for their diagnosis and determination of primary origin. Two hundred and twenty-eight malignant (132 male, 96 female) and 185 benign (132 male, 53 female) PEs were investigated. Statistical analyses evaluated the diagnostic performance parameters in all PEs and in cytologically negative malignant PEs, the association between hMAM and benign or malignant status by the direct index of correlation [diagnostic odds ratio (DOR)], χ test, and P value (P). In addition, the discriminative diagnostic power of hMAM expression, independently in breast cancer, lung cancer (LC), malignant mesothelioma (MM), and other cancers was evaluated. In the entire patient population, hMAM was detected in 45.6% and 5.4% of malignant and benign PEs, respectively, in the male group in 41.7% and 4.5% and in the female group in 51.0% and 7.5% of malignant and benign PEs, respectively. A statistically significant correlation between hMAM and malignancy was found in the entire population (DOR=14.68, P

Original languageEnglish
Pages (from-to)92-98
Number of pages7
JournalDiagnostic Molecular Pathology
Volume19
Issue number2
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Human mammaglobin
  • Malignant pleural effusion
  • Reverse-transcriptase polymerase chain reaction

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pathology and Forensic Medicine

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