Drug-induced interstitial lung diseases (DI-ILD) are the most common clinical pattern of iatrogenic pathology of the respiratory tract. The prevalence of DI-ILD in Italy has been estimated at 1.7% (from data in the Italian Register of Interstitial Lung Diseases). The pathogenesis can be immunologic, due to changes in homeostatic systems (oxidants/ antioxidants, proteases/antiproteases), or to changes in collagen balance or to intracellular drug accumulation with changes in enzyme systems. Major risk factors are age, cumulative drug dosage, underlying disease, and even earlier radiotherapy and oxygen treatment. Diagnosis is based on the temporal relationship between beginning of drug treatment and onset of respiratory symptoms, so that clinical and drug history is the most important diagnostic approach. Only in a few cases can traditional diagnostic tools, such as high-resolution computed tomography (HRCT), bronchoalveolar lavage (BAL) and histology) provide characteristic findings to point to a correct diagnosis. Treatment is the immediate withdrawal of the drug followed by steroid therapy.
|Translated title of the contribution||Diagnosis and therapy of drug-induced interstitial lung diseases|
|Number of pages||13|
|Journal||Rassegna di Patologia dell'Apparato Respiratorio|
|Publication status||Published - Jun 2006|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pulmonary and Respiratory Medicine