Diagnosis and treatment of acromegaly complications

A. Giustina, F. F. Casanueva, F. Cavagnini, P. Chanson, D. Clemmons, L. A. Frohman, R. Gaillard, K. Ho, P. Jaquet, D. L. Kleinberg, S. W J Lamberts, G. Lombardi, M. Sheppard, C. J. Strasburger, M. L. Vance, J. A H Wass, S. Melmed

Research output: Contribution to journalArticlepeer-review

Abstract

The Pituitary Society in conjunction with the European Neuroendocrine Association held a consensus workshop to develop guidelines for diagnosis and treatment of the co-morbid complications of acromegaly. Fifty nine pituitary specialists. (endocrinologists, neurosurgeons and cardiologists) assessed the current published literature on acromegaly complications in light of recent advances in maintaining tight therapeutic control of GH hypersecretion. The impact of elevated GH levels on cardiovascular disease, hypertension, diabetes, sleep apnea, colon polyps, bone disease, reproductive disorders, and neuropsychologic complications were considered. Guidelines are proposed for effective management of these complications in the context of overall acromegaly control. When appropriate, requirements for prospective evidence-based studies and surveillance database development are enunciated. Effective management of co-morbid acromegaly complications will lead to improved morbidity and mortality in acromegaly.

Original languageEnglish
Pages (from-to)1242-1247
Number of pages6
JournalJournal of Endocrinological Investigation
Volume26
Issue number12
Publication statusPublished - Dec 2003

Keywords

  • Acromegaly
  • Analogs
  • Cardiovascular complications
  • Diabetes
  • Osteoporosis
  • Respiratory complications
  • Somatostatin
  • Tumors

ASJC Scopus subject areas

  • Endocrinology

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