Diagnosis and treatment of acute alcohol intoxication and alcohol withdrawal syndrome: position paper of the Italian Society on Alcohol

Fabio Caputo, Roberta Agabio, Teo Vignoli, Valentino Patussi, Tiziana Fanucchi, Paolo Cimarosti, Cristina Meneguzzi, Giovanni Greco, Raffaella Rossin, Michele Parisi, Davide Mioni, Sarino Arico', Vincenzo Ostilio Palmieri, Valeria Zavan, Pierluigi Allosio, Patrizia Balbinot, Maria Francesca Amendola, Livia Macciò, Doda Renzetti, Emanuele ScafatoGianni Testino

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Abstract

The chronic use of alcohol can lead to the onset of an alcohol use disorder (AUD). About 50% of subjects with an AUD may develop alcohol withdrawal syndrome (AWS) when they reduce or discontinue their alcohol consumption and, in 3-5% of them, convulsions and delirium tremens (DTs), representing life-threatening complications, may occur. Unfortunately, few physicians are adequately trained in identifying and treating AWS. The Italian Society on Alcohol has, therefore, implemented a task force of specialists to draw up recommendations for the treatment of AWS with the following main results: (1) while mild AWS may not require treatment, moderate and severe AWS need to be pharmacologically treated; (2) out-patient treatment is appropriate in patients with mild or moderate AWS, while patients with severe AWS need to be treated as in-patients; (3) benzodiazepines, BDZs are the "gold standard" for the treatment of AWS and DTs; (4) alpha-2-agonists, beta-blockers, and neuroleptics may be used in association when BDZs do not completely resolve specific persisting symptoms of AWS; (5) in the case of a refractory form of DTs, the use of anaesthetic drugs (propofol and phenobarbital) in an intensive care unit is appropriate; (6) alternatively to BDZs, sodium oxybate, clomethiazole, and tiapride approved in some European Countries for the treatment of AWS may be employed for the treatment of moderate AWS; (7) anti-convulsants are not sufficient to suppress AWS, and they may be used only in association with BDZs for the treatment of refractory forms of convulsions in the course of AWS.

Original languageEnglish
Pages (from-to)143-160
Number of pages18
JournalInternal and Emergency Medicine
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2019

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Caputo, F., Agabio, R., Vignoli, T., Patussi, V., Fanucchi, T., Cimarosti, P., Meneguzzi, C., Greco, G., Rossin, R., Parisi, M., Mioni, D., Arico', S., Palmieri, V. O., Zavan, V., Allosio, P., Balbinot, P., Amendola, M. F., Macciò, L., Renzetti, D., ... Testino, G. (2019). Diagnosis and treatment of acute alcohol intoxication and alcohol withdrawal syndrome: position paper of the Italian Society on Alcohol. Internal and Emergency Medicine, 14(1), 143-160. https://doi.org/10.1007/s11739-018-1933-8