Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: Guidelines from the European Association for Neuro-Oncology

Khê Hoang-Xuan, Eric Bessell, Jacoline Bromberg, Andreas F. Hottinger, Matthias Preusser, Roberta Rudà, Uwe Schlegel, Tali Siegal, Carole Soussain, Ufuk Abacioglu, Nathalie Cassoux, Martina Deckert, Clemens M F Dirven, Andrés J M Ferreri, Francesc Graus, Roger Henriksson, Ulrich Herrlinger, Martin Taphoorn, Riccardo Soffietti, Michael Weller

Research output: Contribution to journalArticle

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Abstract

The management of primary CNS lymphoma is one of the most controversial topics in neuro-oncology because of the complexity of the disease and the very few controlled studies available. In 2013, the European Association of Neuro-Oncology created a multidisciplinary task force to establish evidence-based guidelines for immunocompetent adults with primary CNS lymphoma. In this Review, we present these guidelines, which provide consensus considerations and recommendations for diagnosis, assessment, staging, and treatment of primary CNS lymphoma. Specifically, we address aspects of care related to surgery, systemic and intrathecal chemotherapy, intensive chemotherapy with autologous stem-cell transplantation, radiotherapy, intraocular manifestations, and management of elderly patients. The guidelines should aid clinicians in their daily practice and decision making, and serve as a basis for future investigations in neuro-oncology.

Original languageEnglish
Pages (from-to)e322-e332
JournalThe Lancet Oncology
Volume16
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

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Lymphoma
Guidelines
Drug Therapy
Stem Cell Transplantation
Advisory Committees
Consensus
Decision Making
Radiotherapy
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Medicine(all)

Cite this

Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients : Guidelines from the European Association for Neuro-Oncology. / Hoang-Xuan, Khê; Bessell, Eric; Bromberg, Jacoline; Hottinger, Andreas F.; Preusser, Matthias; Rudà, Roberta; Schlegel, Uwe; Siegal, Tali; Soussain, Carole; Abacioglu, Ufuk; Cassoux, Nathalie; Deckert, Martina; Dirven, Clemens M F; Ferreri, Andrés J M; Graus, Francesc; Henriksson, Roger; Herrlinger, Ulrich; Taphoorn, Martin; Soffietti, Riccardo; Weller, Michael.

In: The Lancet Oncology, Vol. 16, No. 7, 01.07.2015, p. e322-e332.

Research output: Contribution to journalArticle

Hoang-Xuan, K, Bessell, E, Bromberg, J, Hottinger, AF, Preusser, M, Rudà, R, Schlegel, U, Siegal, T, Soussain, C, Abacioglu, U, Cassoux, N, Deckert, M, Dirven, CMF, Ferreri, AJM, Graus, F, Henriksson, R, Herrlinger, U, Taphoorn, M, Soffietti, R & Weller, M 2015, 'Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: Guidelines from the European Association for Neuro-Oncology', The Lancet Oncology, vol. 16, no. 7, pp. e322-e332. https://doi.org/10.1016/S1470-2045(15)00076-5
Hoang-Xuan, Khê ; Bessell, Eric ; Bromberg, Jacoline ; Hottinger, Andreas F. ; Preusser, Matthias ; Rudà, Roberta ; Schlegel, Uwe ; Siegal, Tali ; Soussain, Carole ; Abacioglu, Ufuk ; Cassoux, Nathalie ; Deckert, Martina ; Dirven, Clemens M F ; Ferreri, Andrés J M ; Graus, Francesc ; Henriksson, Roger ; Herrlinger, Ulrich ; Taphoorn, Martin ; Soffietti, Riccardo ; Weller, Michael. / Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients : Guidelines from the European Association for Neuro-Oncology. In: The Lancet Oncology. 2015 ; Vol. 16, No. 7. pp. e322-e332.
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