Diagnosis and treatment of resistant hypertension

Bernard Waeber, Massimo Volpe, Luis M. Ruilope, Roland E. Schmieder

Research output: Contribution to journalArticle

Abstract

Hypertension resistant to lifestyle interventions and antihypertensive medications is a common problem encountered by physicians in everyday practice. It is most often defined as a blood pressure remaining ≥ 140/90 mmHg despite the regular intake of at least three drugs lowering blood pressure by different mechanisms, one of them being a diuretic. It now appears justified to include, unless contraindicated or not tolerated, a blocker of the renin-angiotensin system and a calcium channel blocker in this drug regimen, not only to gain antihypertensive efficacy, but also to prevent or regress target organ damage and delay the development of cardiorenal complications. A non-negligible fraction of treatment-resistant hypertension have normal "out of office" blood pressures. Ambulatory blood pressure monitoring and/or home blood pressure recording should therefore be routinely performed to identify patients with true resistant hypertension, i.e. patients who are more likely to benefit from treatment intensification.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalBlood Pressure
Volume23
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Blood Pressure
Hypertension
Antihypertensive Agents
Ambulatory Blood Pressure Monitoring
Calcium Channel Blockers
Therapeutics
Renin-Angiotensin System
Diuretics
Pharmaceutical Preparations
Life Style
Physicians

Keywords

  • Ambulatory blood pressure monitoring
  • Combination therapy (antihypertensive medications)
  • Diuretic therapy
  • Hypertension guidelines (hypertension)
  • Refractory hypertension
  • Renin-angiotensin-aldosterone system
  • Self-measurement of blood pressure

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Diagnosis and treatment of resistant hypertension. / Waeber, Bernard; Volpe, Massimo; Ruilope, Luis M.; Schmieder, Roland E.

In: Blood Pressure, Vol. 23, No. 4, 2014, p. 193-199.

Research output: Contribution to journalArticle

Waeber, B, Volpe, M, Ruilope, LM & Schmieder, RE 2014, 'Diagnosis and treatment of resistant hypertension', Blood Pressure, vol. 23, no. 4, pp. 193-199. https://doi.org/10.3109/08037051.2013.854946
Waeber, Bernard ; Volpe, Massimo ; Ruilope, Luis M. ; Schmieder, Roland E. / Diagnosis and treatment of resistant hypertension. In: Blood Pressure. 2014 ; Vol. 23, No. 4. pp. 193-199.
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