Diagnosis and typing of human papillomavirus by non isotopic in situ hybridization in cervical smears

M. Confortini; S. Ciatto; S. Cecchini; C. Maddau; V. Massimo; P. Minuti; F. Carozzi

Diagnosis and typing of human papillomavirus by non isotopic in situ hybridization in cervical smears

M. Confortini, S. Ciatto, S. Cecchini, C. Maddau, V. Massimo, P. Minuti, F. Carozzi

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Smears from four hundred and nine patients were studied for the presence and typing of HPV by non isotopic NISH. Cases eligible for the study were: a) 170 consecutive smears with classic cytologic signs of HPV associated with GIN; b) 219 consecutive cases with histologic evidence of HPV infection; c) 20 consecutive cases self-referring to colposcopy showing non cytologic or colposcopic abnormalities. Immediately before colposcopy 3 smears were taken from each patient and a NISH assay was performed using a mixer and typing test for HPV. The results showed a limited association of cytologic or histologic evidence of HPV to ISH positivity, especially when non classic morphologic criteria were considered.

Original language	English
Pages (from-to)	93-95
Number of pages	3
Journal	Cervix and the Lower Female Genital Tract
Volume	12
Issue number	3
Publication status	Published - 1994

Keywords

Human papillomavirus
In situ hybridization
Pap-smears

ASJC Scopus subject areas

Obstetrics and Gynaecology

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abstract = "Smears from four hundred and nine patients were studied for the presence and typing of HPV by non isotopic NISH. Cases eligible for the study were: a) 170 consecutive smears with classic cytologic signs of HPV associated with GIN; b) 219 consecutive cases with histologic evidence of HPV infection; c) 20 consecutive cases self-referring to colposcopy showing non cytologic or colposcopic abnormalities. Immediately before colposcopy 3 smears were taken from each patient and a NISH assay was performed using a mixer and typing test for HPV. The results showed a limited association of cytologic or histologic evidence of HPV to ISH positivity, especially when non classic morphologic criteria were considered.",

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T1 - Diagnosis and typing of human papillomavirus by non isotopic in situ hybridization in cervical smears

AU - Confortini, M.

AU - Ciatto, S.

AU - Cecchini, S.

AU - Maddau, C.

AU - Massimo, V.

AU - Minuti, P.

AU - Carozzi, F.

PY - 1994

Y1 - 1994

N2 - Smears from four hundred and nine patients were studied for the presence and typing of HPV by non isotopic NISH. Cases eligible for the study were: a) 170 consecutive smears with classic cytologic signs of HPV associated with GIN; b) 219 consecutive cases with histologic evidence of HPV infection; c) 20 consecutive cases self-referring to colposcopy showing non cytologic or colposcopic abnormalities. Immediately before colposcopy 3 smears were taken from each patient and a NISH assay was performed using a mixer and typing test for HPV. The results showed a limited association of cytologic or histologic evidence of HPV to ISH positivity, especially when non classic morphologic criteria were considered.

AB - Smears from four hundred and nine patients were studied for the presence and typing of HPV by non isotopic NISH. Cases eligible for the study were: a) 170 consecutive smears with classic cytologic signs of HPV associated with GIN; b) 219 consecutive cases with histologic evidence of HPV infection; c) 20 consecutive cases self-referring to colposcopy showing non cytologic or colposcopic abnormalities. Immediately before colposcopy 3 smears were taken from each patient and a NISH assay was performed using a mixer and typing test for HPV. The results showed a limited association of cytologic or histologic evidence of HPV to ISH positivity, especially when non classic morphologic criteria were considered.

KW - Human papillomavirus

KW - In situ hybridization

KW - Pap-smears

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