Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment: DiMoPEx-project is designed to determine the impacts of environmental exposure on human health

Lygia Therese Budnik, Balazs Adam, Maria Albin, Barbara Banelli, Xaver Baur, Fiorella Belpoggi, Claudia Bolognesi, Karin Broberg, Per Gustavsson, Thomas Göen, Axel Fischer, Dorota Jarosinska, Fabiana Manservisi, Richard O'Kennedy, Johan Øvrevik, Elizabet Paunovic, Beate Ritz, Paul T.J. Scheepers, Vivi Schlünssen, Heidi SchwarzenbachPer E. Schwarze, Orla Sheils, Torben Sigsgaard, Karel Van Damme, Ludwine Casteleyn

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The WHO has ranked environmental hazardous exposures in the living and working environment among the top risk factors for chronic disease mortality. Worldwide, about 40 million people die each year from noncommunicable diseases (NCDs) including cancer, diabetes, and chronic cardiovascular, neurological and lung diseases. The exposure to ambient pollution in the living and working environment is exacerbated by individual susceptibilities and lifestyle-driven factors to produce complex and complicated NCD etiologies. Research addressing the links between environmental exposure and disease prevalence is key for prevention of the pandemic increase in NCD morbidity and mortality. However, the long latency, the chronic course of some diseases and the necessity to address cumulative exposures over very long periods does mean that it is often difficult to identify causal environmental exposures. EU-funded COST Action DiMoPEx is developing new concepts for a better understanding of health-environment (including gene-environment) interactions in the etiology of NCDs. The overarching idea is to teach and train scientists and physicians to learn how to include efficient and valid exposure assessments in their research and in their clinical practice in current and future cooperative projects. DiMoPEx partners have identified some of the emerging research needs, which include the lack of evidence-based exposure data and the need for human-equivalent animal models mirroring human lifespan and low-dose cumulative exposures. Utilizing an interdisciplinary approach incorporating seven working groups, DiMoPEx will focus on aspects of air pollution with particulate matter including dust and fibers and on exposure to low doses of solvents and sensitizing agents. Biomarkers of early exposure and their associated effects as indicators of disease-derived information will be tested and standardized within individual projects. Risks arising from some NCDs, like pneumoconioses, cancers and allergies, are predictable and preventable. Consequently, preventative action could lead to decreasing disease morbidity and mortality for many of the NCDs that are of major public concern. DiMoPEx plans to catalyze and stimulate interaction of scientists with policy-makers in attacking these exposure-related diseases.

Original languageEnglish
Article number6
JournalJournal of Occupational Medicine and Toxicology
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 5 2018

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Environmental Exposure
Health
monitoring
Disease
Monitoring
health
mortality
Mortality
etiology
Chronic Disease
morbidity
Research
cancer
Morbidity
Pneumoconiosis
Gene-Environment Interaction
Allergies
Particulate Matter
Pulmonary diseases
Air Pollution

Keywords

  • Environmental/occupational exposure to xenobiotics
  • Human biomonitoring
  • Noncommunicable diseases

ASJC Scopus subject areas

  • Toxicology
  • Safety Research
  • Public Health, Environmental and Occupational Health

Cite this

Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment : DiMoPEx-project is designed to determine the impacts of environmental exposure on human health. / Budnik, Lygia Therese; Adam, Balazs; Albin, Maria; Banelli, Barbara; Baur, Xaver; Belpoggi, Fiorella; Bolognesi, Claudia; Broberg, Karin; Gustavsson, Per; Göen, Thomas; Fischer, Axel; Jarosinska, Dorota; Manservisi, Fabiana; O'Kennedy, Richard; Øvrevik, Johan; Paunovic, Elizabet; Ritz, Beate; Scheepers, Paul T.J.; Schlünssen, Vivi; Schwarzenbach, Heidi; Schwarze, Per E.; Sheils, Orla; Sigsgaard, Torben; Van Damme, Karel; Casteleyn, Ludwine.

In: Journal of Occupational Medicine and Toxicology, Vol. 13, No. 1, 6, 05.02.2018.

Research output: Contribution to journalReview article

Budnik, LT, Adam, B, Albin, M, Banelli, B, Baur, X, Belpoggi, F, Bolognesi, C, Broberg, K, Gustavsson, P, Göen, T, Fischer, A, Jarosinska, D, Manservisi, F, O'Kennedy, R, Øvrevik, J, Paunovic, E, Ritz, B, Scheepers, PTJ, Schlünssen, V, Schwarzenbach, H, Schwarze, PE, Sheils, O, Sigsgaard, T, Van Damme, K & Casteleyn, L 2018, 'Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment: DiMoPEx-project is designed to determine the impacts of environmental exposure on human health', Journal of Occupational Medicine and Toxicology, vol. 13, no. 1, 6. https://doi.org/10.1186/s12995-018-0186-9
Budnik, Lygia Therese ; Adam, Balazs ; Albin, Maria ; Banelli, Barbara ; Baur, Xaver ; Belpoggi, Fiorella ; Bolognesi, Claudia ; Broberg, Karin ; Gustavsson, Per ; Göen, Thomas ; Fischer, Axel ; Jarosinska, Dorota ; Manservisi, Fabiana ; O'Kennedy, Richard ; Øvrevik, Johan ; Paunovic, Elizabet ; Ritz, Beate ; Scheepers, Paul T.J. ; Schlünssen, Vivi ; Schwarzenbach, Heidi ; Schwarze, Per E. ; Sheils, Orla ; Sigsgaard, Torben ; Van Damme, Karel ; Casteleyn, Ludwine. / Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment : DiMoPEx-project is designed to determine the impacts of environmental exposure on human health. In: Journal of Occupational Medicine and Toxicology. 2018 ; Vol. 13, No. 1.
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AU - Fischer, Axel

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AU - Paunovic, Elizabet

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AU - Scheepers, Paul T.J.

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