Abstract
An underlying disease affecting bone health is present in up to 40 and 60% of osteoporotic postmenopausal women and men respectively. Among the disorders leading to a secondary form of osteoporosis, the endocrine diseases are highly represented. A frequent finding in patients affected with an endocrine-related forms of bone disease is that the skeletal fragility is partially independent of the bone density, since the fracture risk in these patients is related more to a reduction of bone quality than to a decrease of bone mass. As a consequence, bone mineral density evaluation by dual-X-ray absorptiometry may be inadequate for establishing the risk of fracture in the setting of the endocrinerelated forms of osteoporosis. In the recent years, several attempts to non-invasively estimating bone quality have been done. Nowadays, some new tools are available in the clinic al practice for optimising the fracture risk estimation in patients with endocrine disorders. The aim of this review is to summarise the evidence regarding the role of the different imaging tools for evaluating bone density and bone qua lity in the most frequent forms of endocrine-related osteoporosis, such as obesity, diabetes, acromegaly, thyrotoxicosis, primary hyperparathyroidism, hypercortisolism and hypogonadism. For each of these disorders, data regarding both the current available tools and the future possible new techniques for assessing bone fragility in patient s with endocrine diseases are reported.
| Original language | English |
|---|---|
| Pages (from-to) | R213-R232 |
| Journal | European Journal of Endocrinology |
| Volume | 180 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1 2019 |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Diagnosis of Endocrine Disease : Evaluation of bone fragility in endocrine disorders. / Eller-Vainicher, Cristina; Falchetti, Alberto; Gennari, Luigi; Cairoli, Elisa; Bertoldo, Francesco; Vescini, Fabio; Scillitani, Alfredo; Chiodini, Iacopo.
In: European Journal of Endocrinology, Vol. 180, No. 6, 01.06.2019, p. R213-R232.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Diagnosis of Endocrine Disease
T2 - Evaluation of bone fragility in endocrine disorders
AU - Eller-Vainicher, Cristina
AU - Falchetti, Alberto
AU - Gennari, Luigi
AU - Cairoli, Elisa
AU - Bertoldo, Francesco
AU - Vescini, Fabio
AU - Scillitani, Alfredo
AU - Chiodini, Iacopo
PY - 2019/6/1
Y1 - 2019/6/1
N2 - An underlying disease affecting bone health is present in up to 40 and 60% of osteoporotic postmenopausal women and men respectively. Among the disorders leading to a secondary form of osteoporosis, the endocrine diseases are highly represented. A frequent finding in patients affected with an endocrine-related forms of bone disease is that the skeletal fragility is partially independent of the bone density, since the fracture risk in these patients is related more to a reduction of bone quality than to a decrease of bone mass. As a consequence, bone mineral density evaluation by dual-X-ray absorptiometry may be inadequate for establishing the risk of fracture in the setting of the endocrinerelated forms of osteoporosis. In the recent years, several attempts to non-invasively estimating bone quality have been done. Nowadays, some new tools are available in the clinic al practice for optimising the fracture risk estimation in patients with endocrine disorders. The aim of this review is to summarise the evidence regarding the role of the different imaging tools for evaluating bone density and bone qua lity in the most frequent forms of endocrine-related osteoporosis, such as obesity, diabetes, acromegaly, thyrotoxicosis, primary hyperparathyroidism, hypercortisolism and hypogonadism. For each of these disorders, data regarding both the current available tools and the future possible new techniques for assessing bone fragility in patient s with endocrine diseases are reported.
AB - An underlying disease affecting bone health is present in up to 40 and 60% of osteoporotic postmenopausal women and men respectively. Among the disorders leading to a secondary form of osteoporosis, the endocrine diseases are highly represented. A frequent finding in patients affected with an endocrine-related forms of bone disease is that the skeletal fragility is partially independent of the bone density, since the fracture risk in these patients is related more to a reduction of bone quality than to a decrease of bone mass. As a consequence, bone mineral density evaluation by dual-X-ray absorptiometry may be inadequate for establishing the risk of fracture in the setting of the endocrinerelated forms of osteoporosis. In the recent years, several attempts to non-invasively estimating bone quality have been done. Nowadays, some new tools are available in the clinic al practice for optimising the fracture risk estimation in patients with endocrine disorders. The aim of this review is to summarise the evidence regarding the role of the different imaging tools for evaluating bone density and bone qua lity in the most frequent forms of endocrine-related osteoporosis, such as obesity, diabetes, acromegaly, thyrotoxicosis, primary hyperparathyroidism, hypercortisolism and hypogonadism. For each of these disorders, data regarding both the current available tools and the future possible new techniques for assessing bone fragility in patient s with endocrine diseases are reported.
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UR - http://www.scopus.com/inward/citedby.url?scp=85066292396&partnerID=8YFLogxK
U2 - 10.1530/EJE-18-0991
DO - 10.1530/EJE-18-0991
M3 - Review article
C2 - 31042675
AN - SCOPUS:85066292396
VL - 180
SP - R213-R232
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 6
ER -