Diagnosis of local recurrence after radical prostatectomy

V. Scattoni, F. Montorsi, M. Picchio, M. Roscigno, A. Salonia, P. Rigatti, F. Fazio

Research output: Contribution to journalArticle

Abstract

In the long-term there is biochemical evidence of recurrent prostate carcinoma in ≈40% of patients after radical prostatectomy (RP). Detecting the site of recurrence (local vs distant) is critical for defining the optimum treatment. Pathological and clinical variables, e.g. Gleason score, involvement of seminal vesicles or lymph nodes, margin status at surgery, and especially the timing and pattern of prostate-specific antigen (PSA) recurrence, may help to predict the site of relapse. Transrectal ultrasonography (TRUS) of the prostatic fossa in association with TRUS-guided needle biopsy is considered more sensitive than a digital rectal examination for detecting local recurrence, especially if PSA levels are low. Although it cannot detect minimal tumour mass at very low PSA levels (111In-capromab pendetide scintigraphy and [11]-choline tomography (which are better than conventional imaging for detecting metastatic tumour), have low detection rates for local disease and are considered complementary to TRUS in this setting. Patients with a high PSA after RP may be managed with external beam salvage radiotherapy. An initial PSA of

Original languageEnglish
Pages (from-to)680-688
Number of pages9
JournalBJU International
Volume93
Issue number5
DOIs
Publication statusPublished - Mar 2004

Keywords

  • Biopsy
  • Imaging
  • Prostate cancer
  • Radical prostatectomy
  • Radiotherapy
  • TRUS

ASJC Scopus subject areas

  • Urology

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