Diagnosis of nonventilated hospital-acquired pneumonia: how much do we know?

Otavio T Ranzani, Gennaro De Pascale, Marcelo Park

Research output: Contribution to journalArticlepeer-review


PURPOSE OF REVIEW: To describe the current knowledge about clinical and microbiological diagnosis of nonventilated hospital-acquired pneumonia (NV-HAP).

RECENT FINDINGS: NV-HAP is emerging as a new challenge for clinicians, particularly because VAP incidence has been decreasing. The clinical diagnosis of NV-HAP uses the classical clinical symptoms and signs. However standard evaluation of their accuracy and the evaluation of new criterion (e.g. lung ultrasound) must be conducted particularly in NV-HAP patients. The use of sputum must be encouraged in patients with NV-HAP, assuring its lower respiratory tract representativeness and quality. It is not clear that invasive approaches (e.g. BAL) are associated with improvements in patient-centred outcomes, and further research is needed to assure their correct indication, guaranteeing safety. Rapid diagnosis methods are promising in NV-HAP, particularly for the quick results and information about antibiotic resistance.

SUMMARY: NV-HAP poses several barriers for diagnosis compared with VAP, and the available knowledge is limited. A call for further research in diagnosis of nonventilated HAP is urgent.

Original languageEnglish
Pages (from-to)339-346
Number of pages8
JournalCurrent Opinion in Critical Care
Issue number5
Publication statusPublished - Oct 2018


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