Diagnosis of perinatal stroke II: Mechanisms and clinical phenotypes

P. Govaert, L. Ramenghi, R. Taal, J. Dudink, M. Lequin

Research output: Contribution to journalArticlepeer-review


Introduction: Here (and in an accompanying article dealing with definitions, differential diagnosis and registration), a structured sequential diagnostic flow is proposed to discern clinical phenotypes for perinatal stroke, including arterial ischaemic stroke (AIS), cerebral sinovenous thrombosis (CSVT) and haemorrhagic stroke. Material and results: For neonatal AIS, the diagnostic sequence is infection, trauma, embolism, arteriopathy, other, primary thrombosis and unclassifiable; for neonatal CSVT, the sequence is infection, trauma, venopathy, other, primary thrombosis and unclassifiable. The proposed hierarchical diagnostic flows are an initial step towards a standard for registration of the causes of neonatal stroke. Such standardization should guide attempts at prevention and intervention. An extensive literature search and study of a retrospective cohort of 134 newborn infants with stroke suggest that embolism is the most common identifiable cause for stroke in general (25%), preceding trauma (10%) and infection (8%). Other causes, such as asphyxia, acute blood loss, extracorporeal membrane oxygenation, genetic disorders or prothrombotic conditions, are seen in

Original languageEnglish
Pages (from-to)1720-1726
Number of pages7
JournalActa Paediatrica, International Journal of Paediatrics
Issue number11
Publication statusPublished - 2009


  • Diagnosis
  • Embolism
  • Mechanisms
  • Newborn
  • Stroke

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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