TY - JOUR
T1 - Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis
AU - Gertz, Morie A.
AU - Benson, Merrill D.
AU - Dyck, Peter J.
AU - Grogan, Martha
AU - Coelho, Terresa
AU - Cruz, Marcia
AU - Berk, John L.
AU - Plante-Bordeneuve, Violaine
AU - Schmidt, Hartmut H J
AU - Merlini, Giampaolo
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.
AB - Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.
KW - familial amyloid cardiomyopathy
KW - familial amyloid polyneuropathy
KW - genetics
KW - liver transplantation
UR - http://www.scopus.com/inward/record.url?scp=84961062552&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961062552&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2015.09.075
DO - 10.1016/j.jacc.2015.09.075
M3 - Article
C2 - 26610878
AN - SCOPUS:84961062552
VL - 66
SP - 2451
EP - 2466
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 21
ER -