Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

Morie A. Gertz; Merrill D. Benson; Peter J. Dyck; Martha Grogan; Terresa Coelho; Marcia Cruz; John L. Berk; Violaine Plante-Bordeneuve; Hartmut H J Schmidt; Giampaolo Merlini

doi:10.1016/j.jacc.2015.09.075

Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

Morie A. Gertz, Merrill D. Benson, Peter J. Dyck, Martha Grogan, Terresa Coelho, Marcia Cruz, John L. Berk, Violaine Plante-Bordeneuve, Hartmut H J Schmidt, Giampaolo Merlini

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.

Original language	English
Pages (from-to)	2451-2466
Number of pages	16
Journal	Journal of the American College of Cardiology
Volume	66
Issue number	21
DOIs	https://doi.org/10.1016/j.jacc.2015.09.075
Publication status	Published - Dec 1 2015

Keywords

familial amyloid cardiomyopathy
familial amyloid polyneuropathy
genetics
liver transplantation

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/j.jacc.2015.09.075

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Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis. / Gertz, Morie A.; Benson, Merrill D.; Dyck, Peter J.; Grogan, Martha; Coelho, Terresa; Cruz, Marcia; Berk, John L.; Plante-Bordeneuve, Violaine; Schmidt, Hartmut H J; Merlini, Giampaolo.

In: Journal of the American College of Cardiology, Vol. 66, No. 21, 01.12.2015, p. 2451-2466.

Research output: Contribution to journal › Article › peer-review

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