Accuratezza diagnostica della angiografia coronarica tramite tomografia computerizzata a 64 strati in pazienti con rischio basso-intermedio

Translated title of the contribution: Diagnostic accuracy of 64-slice computed tomography coronary angiography in patients with low-to-intermediate risk

F. Cademartiri, E. Maffei, A. Palumbo, R. Malagò, F. Alberghina, A. Aldrovandi, V. Brambilla, G. Runza, L. La Grutta, A. Menozzi, L. Vignali, G. Casolo, M. Midiri, N. R. Mollet

Research output: Contribution to journalArticle

Abstract

Purpose. Our aim was to evaluate the diagnostic accuracy of 64-slice computed tomography coronary angiography (MSCT-CA) for detecting significant stenosis (≥50% lumen reduction) in a population of patients at low to intermediate risk. Materials and methods. We studied 72 patients (38 men, 34 women, mean age 53.9±8.0 years) with atypical or typical chest pain and stratified in the low-to intermediate risk category. MSCT-CA (Sensation 64 Cardiac, Siemens, Germany) was performed after IV administration of 100 ml of iodinated contrast material (Iomeprol 400 mgI/ml, Bracco, Italy). Two observers, blinded to the results of conventional coronary angiography (CAG), assessed the MSCT-CA scans in consensus. Diagnostic accuracy for detecting significant stenosis was calculated. Results. CAG demonstrated the absence of significant disease in 70.1% of patients (51/72). No patient was excluded from MSCT-CA. There were 37 significant lesions on 1,098 available coronary segments. Sensitivity, specificity and positive and negative predictive value of MSCT-CA for detecting significant coronary artery on a per-segment basis were 100%, 98.6%, 71.2% and 100%, respectively. All patients with at least one significant lesion were correctly identified by MSCT-CA. MSCT-CA scored 15 false positives on a per-segment base, which affected only marginally the per-p.atient performance (only one false positive). Conclusions. We concluded that 64-slice CT-CA is a diagnostic modality with high sensitivity and negative predictive value in patients at low to intermediate risk.

Translated title of the contributionDiagnostic accuracy of 64-slice computed tomography coronary angiography in patients with low-to-intermediate risk
Original languageItalian
Pages (from-to)969-981
Number of pages13
JournalRadiologia Medica
Volume112
Issue number7
DOIs
Publication statusPublished - Oct 2007

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Cademartiri, F., Maffei, E., Palumbo, A., Malagò, R., Alberghina, F., Aldrovandi, A., Brambilla, V., Runza, G., La Grutta, L., Menozzi, A., Vignali, L., Casolo, G., Midiri, M., & Mollet, N. R. (2007). Accuratezza diagnostica della angiografia coronarica tramite tomografia computerizzata a 64 strati in pazienti con rischio basso-intermedio. Radiologia Medica, 112(7), 969-981. https://doi.org/10.1007/s11547-007-0198-5