Diagnostic accuracy of extended-length electrocardiogram in differentiating between athlete's heart and hypertrophic cardiomyopathy

Luigi Caselli, Giorgio Galanti, Luigi Padeletti, Michele Nieri, Franco Cecchi, Franco Cipollini, Massimo Baldi, Laura Perrotta, Simone Vignini, Antonio Michelucci

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Standard 12-lead electrocardiogram (ECG) has several limitations in solving the differential diagnosis between physiologic left ventricular hypertrophy (PLVH) and hypertrophic cardiomyopathy (HCM), given the high rate of false-positive results in athletes. The aim of this study was to assess the usefulness of several arrhythmic risk indexes in differentiating PLVH from HCM. Methods: A multiparametric ECG analysis (extended-length ECG) was performed on 30 male athletes with PLVH and 30 male patients with HCM, with homogeneous age distribution. Results: The combination of 4 extended-length ECG variables, namely, corrected QT interval (Bazett), QT dispersion, mean resting heart rate, and low-amplitude signal duration at 25 Hz (low-amplitude signal duration at the end of filtered QRS) displayed remarkable diagnostic accuracy (area under receiver operating characteristic curve, 94%). The same accuracy was obtained replacing QT dispersion with T-wave complexity index. Conclusions: Extended-length ECG can be considered an effective, low-cost, and low time-consuming clinical tool for distinguishing between PLVH and HCM.

Original languageEnglish
Pages (from-to)636-641
Number of pages6
JournalJournal of Electrocardiology
Volume42
Issue number6
DOIs
Publication statusPublished - Nov 2009

Keywords

  • High-resolution electrocardiography
  • Myocardial hypertrophy
  • Noninvasive electrophysiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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