TY - JOUR
T1 - Diagnostic and prognostic significance of β2-microglobulin during HIV infection
AU - Cavalli, Guido
AU - Lopez, Silvano
AU - Franzetti, Fabio
AU - Amprimo, Maria Claudia
AU - Ronchi, Pietro
AU - Cinque, Paola
AU - Rivera, Paola
AU - Gaido, Pier Carlo
AU - Lazzarin, Adriano
PY - 1990/4
Y1 - 1990/4
N2 - The serum levels of β2-microglobulin (β2-m) were determined in 80 intravenous drug addicts (IVDA) with acquired immunodeficiency syndrome (AIDS), in 128 HIV-positive IVDA with persistent generalized lymphadenopathy (PGL) and in 44 HIV-seronegative IVDA. Seventy-two out of 80 (90%) AIDS patients had elevated serum β2-m levels and high levels of β2-m were also found in 105 of 128 (82%) HIV-infected subjects without AIDS. The mean β2-m level was significantly higher in HIV-infected patients with PGL than in HIV-negative IVDA. Nine out of 64 (14%) PGL patients developed AIDS in a period of 24-54 months. In these patients the mean β2-m level (5.16±2.37 mg/1), obtained from sera stored at the first observation, was significantly higher than in the other PGL patients (3.40±1.03 mg/l); in particular, 5 out of 7 PGL patients with β2-m levels >5.0 mg/l showed an advanced disease.
AB - The serum levels of β2-microglobulin (β2-m) were determined in 80 intravenous drug addicts (IVDA) with acquired immunodeficiency syndrome (AIDS), in 128 HIV-positive IVDA with persistent generalized lymphadenopathy (PGL) and in 44 HIV-seronegative IVDA. Seventy-two out of 80 (90%) AIDS patients had elevated serum β2-m levels and high levels of β2-m were also found in 105 of 128 (82%) HIV-infected subjects without AIDS. The mean β2-m level was significantly higher in HIV-infected patients with PGL than in HIV-negative IVDA. Nine out of 64 (14%) PGL patients developed AIDS in a period of 24-54 months. In these patients the mean β2-m level (5.16±2.37 mg/1), obtained from sera stored at the first observation, was significantly higher than in the other PGL patients (3.40±1.03 mg/l); in particular, 5 out of 7 PGL patients with β2-m levels >5.0 mg/l showed an advanced disease.
KW - β-microglobulin
KW - Acquired immunodeficiency syndrome
KW - Human immunodeficiency virus
KW - Intravenous drug addicts
KW - Persistent generalized lymphadenopathy
UR - http://www.scopus.com/inward/record.url?scp=0025408179&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025408179&partnerID=8YFLogxK
U2 - 10.1007/BF02877556
DO - 10.1007/BF02877556
M3 - Article
C2 - 2196662
AN - SCOPUS:0025408179
VL - 20
SP - 105
EP - 111
JO - Ricerca in Clinica e in Laboratorio
JF - Ricerca in Clinica e in Laboratorio
SN - 0940-5437
IS - 2
ER -