Diagnostic and prognostic significance of β2-microglobulin during HIV infection

Guido Cavalli; Silvano Lopez; Fabio Franzetti; Maria Claudia Amprimo; Pietro Ronchi; Paola Cinque; Paola Rivera; Pier Carlo Gaido; Adriano Lazzarin

doi:10.1007/BF02877556

Diagnostic and prognostic significance of β₂-microglobulin during HIV infection

Guido Cavalli, Silvano Lopez, Fabio Franzetti, Maria Claudia Amprimo, Pietro Ronchi, Paola Cinque, Paola Rivera, Pier Carlo Gaido, Adriano Lazzarin

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The serum levels of β₂-microglobulin (β₂-m) were determined in 80 intravenous drug addicts (IVDA) with acquired immunodeficiency syndrome (AIDS), in 128 HIV-positive IVDA with persistent generalized lymphadenopathy (PGL) and in 44 HIV-seronegative IVDA. Seventy-two out of 80 (90%) AIDS patients had elevated serum β₂-m levels and high levels of β₂-m were also found in 105 of 128 (82%) HIV-infected subjects without AIDS. The mean β₂-m level was significantly higher in HIV-infected patients with PGL than in HIV-negative IVDA. Nine out of 64 (14%) PGL patients developed AIDS in a period of 24-54 months. In these patients the mean β₂-m level (5.16±2.37 mg/1), obtained from sera stored at the first observation, was significantly higher than in the other PGL patients (3.40±1.03 mg/l); in particular, 5 out of 7 PGL patients with β₂-m levels >5.0 mg/l showed an advanced disease.

Original language	English
Pages (from-to)	105-111
Number of pages	7
Journal	La Ricerca in Clinica e in Laboratorio
Volume	20
Issue number	2
DOIs	https://doi.org/10.1007/BF02877556
Publication status	Published - Apr 1990

Keywords

β-microglobulin
Acquired immunodeficiency syndrome
Human immunodeficiency virus
Intravenous drug addicts
Persistent generalized lymphadenopathy

ASJC Scopus subject areas

Clinical Biochemistry

Access to Document

10.1007/BF02877556

Cite this

Diagnostic and prognostic significance of β₂-microglobulin during HIV infection. / Cavalli, Guido; Lopez, Silvano; Franzetti, Fabio; Amprimo, Maria Claudia; Ronchi, Pietro; Cinque, Paola; Rivera, Paola; Gaido, Pier Carlo; Lazzarin, Adriano.

In: La Ricerca in Clinica e in Laboratorio, Vol. 20, No. 2, 04.1990, p. 105-111.

Research output: Contribution to journal › Article › peer-review

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