Diagnostic and prognostic significance of β2-microglobulin during HIV infection

Guido Cavalli, Silvano Lopez, Fabio Franzetti, Maria Claudia Amprimo, Pietro Ronchi, Paola Cinque, Paola Rivera, Pier Carlo Gaido, Adriano Lazzarin

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The serum levels of β2-microglobulin (β2-m) were determined in 80 intravenous drug addicts (IVDA) with acquired immunodeficiency syndrome (AIDS), in 128 HIV-positive IVDA with persistent generalized lymphadenopathy (PGL) and in 44 HIV-seronegative IVDA. Seventy-two out of 80 (90%) AIDS patients had elevated serum β2-m levels and high levels of β2-m were also found in 105 of 128 (82%) HIV-infected subjects without AIDS. The mean β2-m level was significantly higher in HIV-infected patients with PGL than in HIV-negative IVDA. Nine out of 64 (14%) PGL patients developed AIDS in a period of 24-54 months. In these patients the mean β2-m level (5.16±2.37 mg/1), obtained from sera stored at the first observation, was significantly higher than in the other PGL patients (3.40±1.03 mg/l); in particular, 5 out of 7 PGL patients with β2-m levels >5.0 mg/l showed an advanced disease.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalLa Ricerca in Clinica e in Laboratorio
Issue number2
Publication statusPublished - Apr 1990


  • β-microglobulin
  • Acquired immunodeficiency syndrome
  • Human immunodeficiency virus
  • Intravenous drug addicts
  • Persistent generalized lymphadenopathy

ASJC Scopus subject areas

  • Clinical Biochemistry


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