Diagnostic and prognostic tumor markers in the gastrointestinal tract

Ettore Seregni, Leonardo Ferrari, Antonia Martinetti, Emilio Bombardieri

Research output: Contribution to journalArticlepeer-review


The gastrointestinal tract is the most common site of malignancies of any anatomic system in the body. An early detection of primary tumors of the bowel, pancreas, liver, stomach, and esophagus is often difficult in asymptomatic patients and for this reason these tumors are often detected at a relatively advanced stage, when symptoms lead to a diagnostic evaluation. Furthermore, gastrointestinal tract tumors have an extremely variable prognosis; thus, the identification of new prognostic parameters may be useful for selecting patients to more tailored therapies. In this work, the main molecular, genetic, tissular, and circulating tumor markers proposed for diagnosis and prognosis of gastrointestinal malignancies are reviewed and discussed.

Original languageEnglish
Pages (from-to)147-166
Number of pages20
JournalSeminars in Surgical Oncology
Issue number2
Publication statusPublished - 2001


  • Carcinoembryonic antigen
  • Gastrointestinal neoplasms
  • Genes, APC
  • Genes, bcl-2
  • Genes, c-erB2
  • Genes, DCC
  • Genes, p53
  • Genes, ras
  • Matrix metalloproteinases
  • Thymidine phosphorylase
  • Thymidylate synthase
  • Tumor markers,biological

ASJC Scopus subject areas

  • Surgery
  • Oncology


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