Diagnostic and prognostic value of gated myocardial perfusion single-photon emission computed tomography in low-risk patients with left bundle-branch block

Laura Evangelista, Luca Nai Fovino, Francesca Saladini, Giorgio Saladini, Renato Razzolini, Gino Paolo Mormino, Adil Al-Nahhas, Domenico Rubello

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: The abnormal left ventricular activation pattern in patients with a left bundle-branch block (LBBB) frequently induces myocardial perfusion defects, decreasing the specificity of noninvasive coronary-risk stratification with stress testing. We assessed the diagnostic and prognostic impact of gated single-photon emission computed tomography (SPECT) in low-risk patients with LBBB. METHODS: A total of 114 patients underwent dual-day protocol Tc-99m sestamibi gated SPECT and were divided into two subsets: without LBBB (group 1, n=57) and with LBBB (group 2, n=57). Sixty-eight (60%) patients had negative coronary angiography and 46 (40%) were at a low risk for coronary artery disease. The variables incorporating the extent and severity of perfusion defects were calculated: summed stress score, summed rest score and summed difference score, end-diastolic volume (EDV), end-systolic volume (ESV), and left ventricular ejection fraction. The mean variations in EDV and ESV were computed as follows: rest volume-poststress volume. Cardiac events were classified as major and minor. RESULTS: Gated SPECT was positive in eight (14%) patients of group 1 and 33 (58%) patients of group 2 (P

Original languageEnglish
Pages (from-to)491-497
Number of pages7
JournalNuclear Medicine Communications
Volume33
Issue number5
DOIs
Publication statusPublished - May 2012

Keywords

  • coronary artery disease
  • left bundle-branch block
  • myocardial perfusion imaging
  • prognosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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