Diagnostic and prognostic value of gated myocardial perfusion single-photon emission computed tomography in low-risk patients with left bundle-branch block

Laura Evangelista, Luca Nai Fovino, Francesca Saladini, Giorgio Saladini, Renato Razzolini, Gino Paolo Mormino, Adil Al-Nahhas, Domenico Rubello

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: The abnormal left ventricular activation pattern in patients with a left bundle-branch block (LBBB) frequently induces myocardial perfusion defects, decreasing the specificity of noninvasive coronary-risk stratification with stress testing. We assessed the diagnostic and prognostic impact of gated single-photon emission computed tomography (SPECT) in low-risk patients with LBBB. METHODS: A total of 114 patients underwent dual-day protocol Tc-99m sestamibi gated SPECT and were divided into two subsets: without LBBB (group 1, n=57) and with LBBB (group 2, n=57). Sixty-eight (60%) patients had negative coronary angiography and 46 (40%) were at a low risk for coronary artery disease. The variables incorporating the extent and severity of perfusion defects were calculated: summed stress score, summed rest score and summed difference score, end-diastolic volume (EDV), end-systolic volume (ESV), and left ventricular ejection fraction. The mean variations in EDV and ESV were computed as follows: rest volume-poststress volume. Cardiac events were classified as major and minor. RESULTS: Gated SPECT was positive in eight (14%) patients of group 1 and 33 (58%) patients of group 2 (P

Original languageEnglish
Pages (from-to)491-497
Number of pages7
JournalNuclear Medicine Communications
Volume33
Issue number5
DOIs
Publication statusPublished - May 2012

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Bundle-Branch Block
Single-Photon Emission-Computed Tomography
Perfusion
Coronary Angiography
Stroke Volume
Coronary Artery Disease

Keywords

  • coronary artery disease
  • left bundle-branch block
  • myocardial perfusion imaging
  • prognosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Diagnostic and prognostic value of gated myocardial perfusion single-photon emission computed tomography in low-risk patients with left bundle-branch block. / Evangelista, Laura; Nai Fovino, Luca; Saladini, Francesca; Saladini, Giorgio; Razzolini, Renato; Mormino, Gino Paolo; Al-Nahhas, Adil; Rubello, Domenico.

In: Nuclear Medicine Communications, Vol. 33, No. 5, 05.2012, p. 491-497.

Research output: Contribution to journalArticle

Evangelista, Laura ; Nai Fovino, Luca ; Saladini, Francesca ; Saladini, Giorgio ; Razzolini, Renato ; Mormino, Gino Paolo ; Al-Nahhas, Adil ; Rubello, Domenico. / Diagnostic and prognostic value of gated myocardial perfusion single-photon emission computed tomography in low-risk patients with left bundle-branch block. In: Nuclear Medicine Communications. 2012 ; Vol. 33, No. 5. pp. 491-497.
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