Diagnostic and prognostic value of low QRS voltages in cardiac AL amyloidosis

Roberta Mussinelli, Francesco Salinaro, Alessio Alogna, Michele Boldrini, Ambra Raimondi, Francesco Musca, Giovanni Palladini, Giampaolo Merlini, Stefano Perlini

Research output: Contribution to journalArticle

Abstract

Background In cardiac AL amyloidosis, myocardial infiltration is typically associated with "low QRS voltages" at the 12-lead electrocardiogram (ECG). Although considered as one of the hallmarks of the disease, its reported prevalence varies from 45% to 70%, mainly because of nonhomogeneous definitions. Methods To identify the "low QRS voltage" parameter having the best diagnostic value in identifying cardiac amyloidosis, and to assess its possible prognostic role, ECG and echocardiographic data were collected at diagnosis in 337 consecutive never-treated AL patients (233 with, 104 without cardiac involvement). Prognosis was assessed after a median follow-up of 14.5 months. Results "Low QRS voltage" prevalence varied from 84.12% when using Sokolow-Lyon index ≤15 mm to 27.04% with the definition of low total voltages (QRS amplitude ≤5 mm in each peripheral and ≤10 mm in each precordial lead), the widely used definition of low peripheral voltages (≤5 mm in each peripheral lead) being able to identify 66.52% cardiac AL patients. The presence of "low peripheral voltages" was associated with a more severe cardiac involvement, and was able to differentiate Mayo stage II patients' survival (i.e., AL patients with intermediate prognosis). According to receiver operator characteristic (ROC) curve analysis, sensitivity and specificity were 58.72% and 80.00%, for a peripheral QRS amplitude ≤24.5 mm (the sum of QRS in all the 6 peripheral leads), and 76.26% and 65.00% for a Sokolow-Lyon index ≤11 mm. Conclusions In cardiac AL amyloidosis the prevalence of low QRS voltages is highly dependent on the method used for defining this ECG alteration.

Original languageEnglish
Pages (from-to)271-280
Number of pages10
JournalAnnals of Noninvasive Electrocardiology
Volume18
Issue number3
DOIs
Publication statusPublished - May 2013

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Amyloidosis
Electrocardiography
Sensitivity and Specificity
Survival
Lead

Keywords

  • amyloid
  • echocardiography
  • electrocardiography
  • low peripheral QRS voltages
  • prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Diagnostic and prognostic value of low QRS voltages in cardiac AL amyloidosis. / Mussinelli, Roberta; Salinaro, Francesco; Alogna, Alessio; Boldrini, Michele; Raimondi, Ambra; Musca, Francesco; Palladini, Giovanni; Merlini, Giampaolo; Perlini, Stefano.

In: Annals of Noninvasive Electrocardiology, Vol. 18, No. 3, 05.2013, p. 271-280.

Research output: Contribution to journalArticle

Mussinelli R, Salinaro F, Alogna A, Boldrini M, Raimondi A, Musca F et al. Diagnostic and prognostic value of low QRS voltages in cardiac AL amyloidosis. Annals of Noninvasive Electrocardiology. 2013 May;18(3):271-280. https://doi.org/10.1111/anec.12036
Mussinelli, Roberta ; Salinaro, Francesco ; Alogna, Alessio ; Boldrini, Michele ; Raimondi, Ambra ; Musca, Francesco ; Palladini, Giovanni ; Merlini, Giampaolo ; Perlini, Stefano. / Diagnostic and prognostic value of low QRS voltages in cardiac AL amyloidosis. In: Annals of Noninvasive Electrocardiology. 2013 ; Vol. 18, No. 3. pp. 271-280.
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T1 - Diagnostic and prognostic value of low QRS voltages in cardiac AL amyloidosis

AU - Mussinelli, Roberta

AU - Salinaro, Francesco

AU - Alogna, Alessio

AU - Boldrini, Michele

AU - Raimondi, Ambra

AU - Musca, Francesco

AU - Palladini, Giovanni

AU - Merlini, Giampaolo

AU - Perlini, Stefano

PY - 2013/5

Y1 - 2013/5

N2 - Background In cardiac AL amyloidosis, myocardial infiltration is typically associated with "low QRS voltages" at the 12-lead electrocardiogram (ECG). Although considered as one of the hallmarks of the disease, its reported prevalence varies from 45% to 70%, mainly because of nonhomogeneous definitions. Methods To identify the "low QRS voltage" parameter having the best diagnostic value in identifying cardiac amyloidosis, and to assess its possible prognostic role, ECG and echocardiographic data were collected at diagnosis in 337 consecutive never-treated AL patients (233 with, 104 without cardiac involvement). Prognosis was assessed after a median follow-up of 14.5 months. Results "Low QRS voltage" prevalence varied from 84.12% when using Sokolow-Lyon index ≤15 mm to 27.04% with the definition of low total voltages (QRS amplitude ≤5 mm in each peripheral and ≤10 mm in each precordial lead), the widely used definition of low peripheral voltages (≤5 mm in each peripheral lead) being able to identify 66.52% cardiac AL patients. The presence of "low peripheral voltages" was associated with a more severe cardiac involvement, and was able to differentiate Mayo stage II patients' survival (i.e., AL patients with intermediate prognosis). According to receiver operator characteristic (ROC) curve analysis, sensitivity and specificity were 58.72% and 80.00%, for a peripheral QRS amplitude ≤24.5 mm (the sum of QRS in all the 6 peripheral leads), and 76.26% and 65.00% for a Sokolow-Lyon index ≤11 mm. Conclusions In cardiac AL amyloidosis the prevalence of low QRS voltages is highly dependent on the method used for defining this ECG alteration.

AB - Background In cardiac AL amyloidosis, myocardial infiltration is typically associated with "low QRS voltages" at the 12-lead electrocardiogram (ECG). Although considered as one of the hallmarks of the disease, its reported prevalence varies from 45% to 70%, mainly because of nonhomogeneous definitions. Methods To identify the "low QRS voltage" parameter having the best diagnostic value in identifying cardiac amyloidosis, and to assess its possible prognostic role, ECG and echocardiographic data were collected at diagnosis in 337 consecutive never-treated AL patients (233 with, 104 without cardiac involvement). Prognosis was assessed after a median follow-up of 14.5 months. Results "Low QRS voltage" prevalence varied from 84.12% when using Sokolow-Lyon index ≤15 mm to 27.04% with the definition of low total voltages (QRS amplitude ≤5 mm in each peripheral and ≤10 mm in each precordial lead), the widely used definition of low peripheral voltages (≤5 mm in each peripheral lead) being able to identify 66.52% cardiac AL patients. The presence of "low peripheral voltages" was associated with a more severe cardiac involvement, and was able to differentiate Mayo stage II patients' survival (i.e., AL patients with intermediate prognosis). According to receiver operator characteristic (ROC) curve analysis, sensitivity and specificity were 58.72% and 80.00%, for a peripheral QRS amplitude ≤24.5 mm (the sum of QRS in all the 6 peripheral leads), and 76.26% and 65.00% for a Sokolow-Lyon index ≤11 mm. Conclusions In cardiac AL amyloidosis the prevalence of low QRS voltages is highly dependent on the method used for defining this ECG alteration.

KW - amyloid

KW - echocardiography

KW - electrocardiography

KW - low peripheral QRS voltages

KW - prognosis

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