Diagnostic and prognostic value of the determination of the aminopropeptide of type III procollagen in patients with primary liver cancer

F. Farinati, G. Annoni, M. F. Donato, P. Nardelli, A. Bertozzo, N. De Maria, S. Zotti, M. Salvagnini, D. Martinez, R. Naccarato

Research output: Contribution to journalArticle

Abstract

Hepatic fibroplasia seems to play an important role in the course of primary liver cancer (PLC) since, for instance, encapsulated and fibrolamellar hepatocellular carcinomas show a definitely better prognosis. In this study, serum procollagen III amino-terminal peptide (PIIIP) levels, which reflect synthesis and release of procollagen type III, were measured with the aim of assessing hepatic fibrogenesis in PLC patients and determining whether serum PIIIP levels play a diagnostic or prognostic role in PLC. Twenty-five patients with PLC, 74 patients with cirrhosis and 38 healthy volunteers were studied. Serum PIIIP levels were determined by a radioimmunoassay (RIA) method. In PLC patients PIIIP serum levels were significantly higher than those of controls and cirrhotic patients (P

Original languageEnglish
Pages (from-to)633-638
Number of pages6
JournalJournal of Gastroenterology and Hepatology
Volume5
Issue number6
Publication statusPublished - 1990

Keywords

  • hepatocellular carcinoma
  • liver cancer
  • liver neoplasm
  • procollagen

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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    Farinati, F., Annoni, G., Donato, M. F., Nardelli, P., Bertozzo, A., De Maria, N., Zotti, S., Salvagnini, M., Martinez, D., & Naccarato, R. (1990). Diagnostic and prognostic value of the determination of the aminopropeptide of type III procollagen in patients with primary liver cancer. Journal of Gastroenterology and Hepatology, 5(6), 633-638.