Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope

Torsten Matthias, Sascha Pfeiffer, Carlo Selmi, M. Eric Gershwin

Research output: Contribution to journalArticlepeer-review


The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, the majority of CD cases are diagnosed with great delay. Recent research into the pathogenesis of CD, allowed us to identify a neo-antigen that appears to be the most promising serological tool for the detection of anti-tissue transglutaminase as well as antigliadin antibodies.

Original languageEnglish
Pages (from-to)298-301
Number of pages4
JournalClinical Reviews in Allergy and Immunology
Issue number2-3
Publication statusPublished - Apr 2010


  • Anti-gliadin antibodies
  • Celiac disease
  • Tissue transglutaminase

ASJC Scopus subject areas

  • Immunology and Allergy


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