Diagnostic difficulties of Lactobacillus casei bacteraemia in immunocompetent patients: A case report

Chiara Tommasi, Francesco Equitani, Marcello Masala, Milva Ballardini, Marco Favaro, Marcello Meledandri, Carla Fontana, Pasquale Narciso, Emanuele Nicastri

Research output: Contribution to journalArticle

Abstract

Introduction: Lactobacilli are currently proposed as probiotic agents in several dietary products. In blood cultures, they are usually considered as contaminants, but in recent years they have been recognized as causal infectious agents of endocarditis, urinary tract infections, meningitis, intra-abdominal infections and bacteraemia. Case presentation: We report a case of Lactobacillus casei bacteraemia in a 66-year-old immunocompetent man with a history of fever of unknown origin. Leuconostoc bacteraemia was demonstrated by blood culture, but a later polymerase chain reaction analysis with sequencing of 16S ribosomal RNA identified Lactobacillus casei and a successful antibiotic therapy was performed. Conclusion: Bacteraemia caused by probiotic organisms is rare but underestimated, since they are normally regarded as contaminants and their role as primary invaders is not always easily established. Although the consumption of probiotic products cannot be considered a risk factor in the development of diseases caused by usually non-pathogenic bacteria, specific individual clinical histories should be taken into account. This report should alert both clinicians and microbiologists to the possibility of unusual pathogens causing serious illnesses and to the use of 16S ribosomal RNA sequencing for molecular identification as a powerful tool in confirming the diagnosis of infrequent pathogens.

Original languageEnglish
Article number315
JournalJournal of Medical Case Reports
Volume2
DOIs
Publication statusPublished - Sep 30 2008

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Lactobacillus casei
Bacteremia
Probiotics
16S Ribosomal RNA
Intraabdominal Infections
RNA Sequence Analysis
Leuconostoc
Fever of Unknown Origin
Lactobacillus
Endocarditis
Meningitis
Urinary Tract Infections
Anti-Bacterial Agents
Bacteria
Polymerase Chain Reaction
Blood Culture
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Diagnostic difficulties of Lactobacillus casei bacteraemia in immunocompetent patients : A case report. / Tommasi, Chiara; Equitani, Francesco; Masala, Marcello; Ballardini, Milva; Favaro, Marco; Meledandri, Marcello; Fontana, Carla; Narciso, Pasquale; Nicastri, Emanuele.

In: Journal of Medical Case Reports, Vol. 2, 315, 30.09.2008.

Research output: Contribution to journalArticle

Tommasi, C, Equitani, F, Masala, M, Ballardini, M, Favaro, M, Meledandri, M, Fontana, C, Narciso, P & Nicastri, E 2008, 'Diagnostic difficulties of Lactobacillus casei bacteraemia in immunocompetent patients: A case report', Journal of Medical Case Reports, vol. 2, 315. https://doi.org/10.1186/1752-1947-2-315
Tommasi, Chiara ; Equitani, Francesco ; Masala, Marcello ; Ballardini, Milva ; Favaro, Marco ; Meledandri, Marcello ; Fontana, Carla ; Narciso, Pasquale ; Nicastri, Emanuele. / Diagnostic difficulties of Lactobacillus casei bacteraemia in immunocompetent patients : A case report. In: Journal of Medical Case Reports. 2008 ; Vol. 2.
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