Diagnostic evaluation of people with hypertension in low income country: Cohort study of "essential" method of risk stratification

Gregorio Montalvo, Fausto Avanzini, Mariella Anselmi, Rosanna Prandi, Samuel Ibarra, Monica Marquez, Daniela Armani, Juan Martín Moreira, Cynthia Caicedo, Maria Carla Roncaglioni, Fabio Colombo, Paola Camisasca, Valentina Milani, Simon Quimì, Felix Gonzabay, Gianni Tognoni

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To explore the predictive power of a risk stratification method for people with hypertension based on "essential" procedures (that is, available in economically less developed areas of the world), comparing it in the same population with the results given by the method suggested by the 1999 World Health Organization-International Society of Hypertension (WHO-ISH) guidelines. Design: Prospective cohort study of outcomes according to cardiovascular risk profile at baseline. Setting: Primary care in a poor rural area of the Ecuadorian forest. Participants: 504 people with hypertension prospectively monitored fora mean of 6.7 (SD 2.3) years. Interventions: Essential data included blood pressure, medical history, smoking, age, sex, and diagnosis of diabetes; the WHO-ISH methods additionally included measurement of fasting blood glucose, total cholesterol, and creatinine, urinalysis, and electrocardiography. Main outcome measures: Cardiovascular events and total deaths. Results: With both methods there was a highly significant association between the level of predicted risk and the incidence of cardiovascular events and of total deaths: up to three quarters of all cardiovascular events and two thirds of all deaths were reported among people classified as at high or very high risk with either method. The predictive discrimination of the essential method is comparable with the WHO-ISH with C statistics (95% confidence interval) of 0.788 (0.721 to 0.855) and 0.744 (0.673 to 0.815), respectively, for cardiovascular events and 0.747 (0.678 to 0.816) and 0.705 (0.632 to 0.778) for total mortality. Conclusions: The risk stratification of patients with hypertension with an essential package of variables (that is, available and practicable even in the economically less developed areas of the world) serves at least as well as the more comprehensive method proposed by WHO-ISH.

Original languageEnglish
Pages (from-to)738-741
Number of pages4
JournalBritish Medical Journal
Volume337
Issue number7672
DOIs
Publication statusPublished - Sep 27 2008

ASJC Scopus subject areas

  • Medicine(all)

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