Diagnostic features and outcome of surgical therapy of acromegalic patients: Experience of the last three decades

Elisa Sala, Emanuele Ferrante, Marco Locatelli, Paolo Rampini, Giovanna Mantovani, Claudia Giavoli, Marcello Filopanti, Elisa Verrua, Elena Malchiodi, Giorgio Carrabba, Maura Arosio, Paolo Beck-Peccoz, Anna Spada, Andrea Gerardo Lania

Research output: Contribution to journalArticle

Abstract

Objective: Transsphenoidal (TNS) surgery remains the primary therapeutic option for GHsecreting pituitary adenomas. The aims of this study were to verify the impact of TNS surgery on treatment of acromegaly before and after identification by a dedicated neurosurgical team and to enumerate diagnostic features of the disease described over three decades. Design: 41 patients (group A) who underwent TNS surgery by a dedicated neurosurgical team (2000- 2008) and 126 patients (group B) operated on by surgeons not specialized in pituitary surgery (1979-1999) were retrospectively analyzed. RESULTS: No significant differences were observed between the two groups in terms of delay of diagnosis, mean basal GH levels and GH nadir values, prevalence of hypopituitarism and hypertension. IGF-I SDS were significantly higher, while prevalence of IGT/diabetes was significantly lower in group B than in group A. Overall remission rate after surgery was 58.5% for group A (75% in microadenomas and 48% in macroadenomas, P=NS) and 37% for group B (P

Original languageEnglish
Pages (from-to)95-103
Number of pages9
JournalHormones
Volume13
Issue number1
Publication statusPublished - 2014

Keywords

  • Acromegaly
  • Microscopic approach
  • Transsphenoidal (TNS) surgery

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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